The possible link between hIAPP accumulation and β-cell death in diabetic patients has
inspired numerous studies focusing on amyloid structures and aggregation pathways of this …

Monitoring blood glucose levels for diabetic patients is critical to achieve tight glycaemic
control. As none of the current antidiabetic treatments restore lost functional β-cell mass in …

Type 2 Diabetes is a major public health threat, and its prevalence is increasing worldwide.
The abnormal accumulation of islet amyloid polypeptide (IAPP) in pancreatic β-cells is …

Type 2 diabetes (T2D) is a common protein misfolding disease (PMD), and its pathogenesis
is considered to be tightly associated with the aggregation of the disease-causative hIAPP …

A series of forty α-substituted chalcones were synthesized and screened for their
antiproliferative activities against HCT116 (colorectal) and HCC1954 (breast) cancer cell …

Type 2 diabetes mellitus (T2DM) and other metabolic disorders are often silent and go
unnoticed in patients because of the lack of suitable prognostic and diagnostic markers. The …

Abstract Type 2 diabetes (T2DM) is associated with aggregation of the human islet amyloid
polypeptide (hIAPP) into cytotoxic amyloid species. Here we tested the effect of a …

4-Arylhydrazinylidene-5-(polyfluoroalkyl) pyrazol-3-ones (4-AHPs) were found to be
obtained by the regiospecific cyclization of 2-arylhydrazinylidene-3-(polyfluoroalkyl)-3 …

Although nuclear magnetic resonance spectroscopy is a potent analytical tool for
identification, quantification, and structural elucidation, it suffers from inherently low …

In humans with type 2 diabetes, at least 70% of patients exhibit islet amyloid plaques formed
by misfolding islet amyloid polypeptides (IAPP). The oligomeric conformation and …