Histone side chains are post-translationally modified at multiple sites, including at Lys36 on
histone H3 (H3K36). Several enzymes from yeast and humans, including the …

Alterations of chromatin structure have been shown to be crucial for response to cell
signaling and for programmed gene expression in development. Posttranslational histone …

The Polycomb repressive complex 2 (PRC2) confers transcriptional repression through
histone H3 lysine 27 trimethylation (H3K27me3). Here, we examined how PRC2 is …

RNA is a critical component of chromatin in eukaryotes, both as a product of transcription,
and as an essential constituent of ribonucleoprotein complexes that regulate both local and …

Dosage compensation is an epigenetic mechanism that normalizes gene expression from
unequal copy numbers of sex chromosomes. Different organisms have evolved alternative …

Dosage compensation is the crucial process that equalizes gene expression from the X
chromosome between males (XY) and females (XX). In Drosophila, the male-specific lethal …

Dosage compensation in Drosophila increases the transcription of genes on the single X
chromosome in males to equal that of both X chromosomes in females. Site-specific histone …

Histone marks, carriers of epigenetic information, regulate gene expression. In mammalian
cells, H3K36me3 is mainly catalyzed by SETD2 at gene body regions. Here, we find that in …

The Drosophila male-specific lethal (MSL) dosage compensation complex increases
transcript levels on the single male X chromosome to equal the transcript levels in XX …

Duplication of eukaryotic genomes during S phase is coordinated in space and time. In
order to identify zones of initiation and cell-type-as well as gender-specific plasticity of DNA …