Rhein (4, 5‐dihydroxyanthraquinone‐2‐carboxylic acid) is a lipophilic anthraquinone
extensively found in medicinal herbs, such as Rheum palmatum L., Cassia tora L …

Rhein is a major medicinal ingredient isolated from several traditional Chinese medicines,
including Rheum palmatum L., Aloe barbadensis Miller, Cassia angustifolia Vahl., and …

Obesity and obesity-related disorders, such as type 2 diabetes have been progressively
increasing worldwide and treatments have failed to counteract their progression. Growing …

Liver fibrosis is a dynamic pathological condition which can be slowed down in its initial
phases. Without proper clinical management of fibrosis, progressive liver damage may lead …

Activated pancreatic stellate cells (PSCs) have been widely accepted as a key precursor of
excessive pancreatic fibrosis, which is a crucial hallmark of chronic pancreatitis (CP) and its …

Background Despite the availability of effective antiretroviral therapies, drugs for HIV-1
treatment with new mode of action are still needed. An innovative approach is aimed to …

D-α-Tocopheryl polyethylene glycol 1000 succinate (TPGS)-modified carboxymethyl
chitosan-rhein (TCR) polymeric micelles (PMs) self-assembled by TCR conjugate were …

An amphiphilic carboxymethyl chitosan-rhein (CR) conjugate was prepared, characterized,
and evaluated as a potential carrier material for oral delivery of paclitaxel (PTX). CR …

Inflammation is a defensive response of living tissues to damaging agents, which exists in
two forms, acute inflammation and chronic inflammation, and chronic inflammation is closely …

Chronic pancreatitis (CP) is a disease characterized by inflammatory recurrence that
accompanies the development of pancreatic fibrosis. As the mystery of CP pathogenesis is …