Protein handling, modification and folding in the endoplasmic reticulum (ER) are tightly
regulated processes that determine cell function, fate and survival. In several tumour types …

Malignant cells utilize diverse strategies that enable them to thrive under adverse conditions
while simultaneously inhibiting the development of anti-tumor immune responses. Hostile …

Ferroptosis is a form of regulated cell death driven by oxidative injury promoting lipid
peroxidation, although detailed molecular regulators are largely unknown. Here, we show …

Dendritic cells (DCs) are required to initiate and sustain T cell-dependent anti-cancer
immunity. However, tumors often evade immune control by crippling normal DC function …

The breakthrough discoveries of leptin and adiponectin more than two decades ago led to a
widespread recognition of adipose tissue as an endocrine organ. Many more adipose tissue …

Background Dihydroartemisinin (DHA) has been shown to exert anticancer activity through
iron-dependent reactive oxygen species (ROS) generation, which is similar to ferroptosis, a …

Reactive oxygen species and reactive nitrogen species are biological molecules that play
important roles in cardiovascular physiology and contribute to disease initiation …

The α, β polyunsaturated lipid aldehydes are potent lipid electrophiles that covalently modify
lipids, proteins, and nucleic acids. Recent work highlights the critical role these lipids play …

Immune responses occur in the midst of a variety of cellular stresses that can severely
perturb endoplasmic reticulum (ER) function. The unfolded protein response is a three …

During the last three decades, 4-hydroxy-2-nonenal (HNE), a major α, β-unsaturated
aldehyde product of n-6 fatty acid oxidation, has been shown to be involved in a great …