Multiple roles of CD90 in cancer

A Kumar, A Bhanja, J Bhattacharyya, BG Jaganathan - Tumor Biology, 2016 - Springer
Abstract THY1 (CD90) is a 25–37-kDa heavily N-glycosylated, glycophosphatidylinositol
(GPI) anchored cell surface protein. It is usually expressed on thymocytes, mesenchymal …

The impact of Epstein-Barr virus infection on epigenetic regulation of host cell gene expression in epithelial and lymphocytic malignancies

MML Leong, ML Lung - Frontiers in Oncology, 2021 - frontiersin.org
Epstein-Barr virus (EBV) infection is associated with a variety of malignancies including
Burkitt's lymphoma (BL), Hodgkin's disease, T cell lymphoma, nasopharyngeal carcinoma …

A reduction in CD90 (THY-1) expression results in increased differentiation of mesenchymal stromal cells

DA Moraes, TT Sibov, LF Pavon, PQ Alvim… - Stem cell research & …, 2016 - Springer
Abstract Background Mesenchymal stromal cells (MSCs) are multipotent progenitor cells
used in several cell therapies. MSCs are characterized by the expression of CD73, CD90 …

A CD90+ Tumor-Initiating Cell Population with an Aggressive Signature and Metastatic Capacity in Esophageal Cancer

KH Tang, YD Dai, M Tong, YP Chan, PS Kwan, L Fu… - Cancer research, 2013 - AACR
Abstract Tumor-initiating cells (TIC), also known as cancer stem cells, are regarded widely
as a specific subpopulation of cells needed for cancer initiation and progression. TICs have …

Extracellular Protease ADAMTS9 Suppresses Esophageal and Nasopharyngeal Carcinoma Tumor Formation by Inhibiting Angiogenesis

PHY Lo, HL Lung, AKL Cheung, SS Apte, KW Chan… - Cancer research, 2010 - AACR
ADAMTS metalloprotease family member ADAMTS9 maps to 3p14. 2 and shows significant
associations with the aerodigestive tract cancers esophageal squamous cell carcinoma …

Anti-angiogenic and tumor-suppressive roles of candidate tumor-suppressor gene, Fibulin-2, in nasopharyngeal carcinoma

EWL Law, AKL Cheung, VI Kashuba, TV Pavlova… - Oncogene, 2012 - nature.com
Abstract Fibulin-2 (FBLN2) has been identified as a candidate tumor-suppressor gene in
nasopharyngeal carcinoma (NPC). Originally identified through a chromosome 3 NotI …

[HTML][HTML] The interplay of host genetic factors and Epstein-Barr virus in the development of nasopharyngeal carcinoma

ML Lung, AKL Cheung, JMY Ko, HL Lung… - Chinese journal of …, 2014 - ncbi.nlm.nih.gov
The interplay between host cell genetics and Epstein-Barr virus (EBV) infection contributes
to the development of nasopharyngeal carcinoma (NPC). Understanding the host genetic …

Overexpression of Thy1/CD90 in human hepatocellular carcinoma is associated with HBV infection and poor prognosis

JW Lu, JG Chang, KT Yeh, RM Chen, JJP Tsai, RM Hu - Acta histochemica, 2011 - Elsevier
Thy1/CD90 is an important marker of many types of stem cells. It functions as a tumor
suppressor in ovarian cancer and in nasopharyngeal carcinoma. In this study, the …

The landscape of candidate driver genes differs between male and female breast cancer

I Johansson, M Ringnér, I Hedenfalk - PloS one, 2013 - journals.plos.org
The rapidly growing collection of diverse genome-scale data from multiple tumor types
sheds light on various aspects of the underlying tumor biology. With the objective to identify …

[HTML][HTML] Glioma cell VEGFR-2 confers resistance to chemotherapeutic and antiangiogenic treatments in PTEN-deficient glioblastoma

T Kessler, F Sahm, J Blaes, M Osswald, P Rübmann… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Loss of the tumor suppressor phosphatase and tensin homolog deleted on chromosome 10
(PTEN) is a prerequisite for tumor cell-specific expression of vascular endothelial growth …