Antimicrobial therapeutic drug monitoring in critically ill adult patients: a Position Paper#
Abstract Purpose This Position Paper aims to review and discuss the available data on
therapeutic drug monitoring (TDM) of antibacterials, antifungals and antivirals in critically ill …
therapeutic drug monitoring (TDM) of antibacterials, antifungals and antivirals in critically ill …
Pharmacokinetic/pharmacodynamic parameters: rationale for antibacterial dosing of mice and men
WA Craig - Clinical infectious diseases, 1998 - JSTOR
The pharmacology of antimicrobial therapy can be divided into two distinct components
(figure 1). The first of these components is pharmacokinetics, or the absorption, distribution …
(figure 1). The first of these components is pharmacokinetics, or the absorption, distribution …
Pharmacokinetic issues for antibiotics in the critically ill patient
JA Roberts, J Lipman - Critical care medicine, 2009 - journals.lww.com
Objective: To discuss the altered pharmacokinetic properties of selected antibiotics in
critically ill patients and to develop basic dose adjustment principles for this patient …
critically ill patients and to develop basic dose adjustment principles for this patient …
Pharmacokinetic-pharmacodynamic modeling of antibacterial drugs
Pharmacokinetic-pharmacodynamic (PKPD) modeling and simulation has evolved as an
important tool for rational drug development and drug use, where developed models …
important tool for rational drug development and drug use, where developed models …
What antibiotic exposures are required to suppress the emergence of resistance for gram-negative bacteria? A systematic review
Background The rates of antibiotic resistance in Gram-negative bacteria are increasing. One
method to minimize resistance emergence may be optimization of antibiotic dosing …
method to minimize resistance emergence may be optimization of antibiotic dosing …
Fluoroquinolones in animal health
SA Brown - Journal of veterinary pharmacology and …, 1996 - Wiley Online Library
The fluoroquinolones are a series of synthetic antibacterial agents that are undergoing
extensive investigation for both human and veterinary use in the treatment of a variety of …
extensive investigation for both human and veterinary use in the treatment of a variety of …
Experience with a once-daily aminoglycoside program administered to 2,184 adult patients
DP Nicolau, CD Freeman, PP Belliveau… - Antimicrobial agents …, 1995 - Am Soc Microbiol
Once-daily aminoglycoside (ODA) regimens have been instituted to maximize bacterial
killing by optimizing the peak concentration/MIC ratio and to reduce the potential for toxicity …
killing by optimizing the peak concentration/MIC ratio and to reduce the potential for toxicity …
The mutant selection window and antimicrobial resistance
K Drlica - Journal of Antimicrobial Chemotherapy, 2003 - academic.oup.com
The mutant selection window is an antimicrobial concentration range extending from the
minimal concentration required to block the growth of wild-type bacteria up to that required …
minimal concentration required to block the growth of wild-type bacteria up to that required …
Pharmacology of the fluoroquinolones: a perspective for the use in domestic animals
M Martinez, P McDermott, R Walker - The Veterinary Journal, 2006 - Elsevier
The fluoroquinolones are a class of compounds that comprise a large and expanding group
of synthetic antimicrobial agents. Structurally, all fluoroquinolones contain a fluorine …
of synthetic antimicrobial agents. Structurally, all fluoroquinolones contain a fluorine …
A critical review of the fluoroquinolones: focus on respiratory tract infections
GG Zhanel, K Ennis, L Vercaigne, A Walkty, AS Gin… - Drugs, 2002 - Springer
The new fluoroquinolones (clinafloxacin, gatifloxacin, gemifloxacin, grepafloxacin,
levofloxacin, moxifloxacin, sitafloxacin, sparfloxacin and trovafloxacin) offer excellent activity …
levofloxacin, moxifloxacin, sitafloxacin, sparfloxacin and trovafloxacin) offer excellent activity …