Most cancer-associated deaths occur due to metastasis, yet our understanding of metastasis
as an evolving, heterogeneous, systemic disease and of how to effectively treat it is still …

Chromosomal instability (CIN) refers to an increased propensity of cells to acquire structural
and numerical chromosomal abnormalities during cell division, which contributes to tumour …

Cancers are a group of heterogeneous diseases characterized by the acquisition of
functional capabilities during the transition from a normal to a neoplastic state. Powerful …

The paradigm for macrophage characterization has evolved from the simple M1/M2
dichotomy to a more complex model that encompasses the broad spectrum of macrophage …

The ability to explore life kingdoms is largely driven by innovations and breakthroughs in
technology, from the invention of the microscope 350 years ago to the recent emergence of …

Acral melanoma is a dismal subtype of melanoma occurring in glabrous acral skin, and has
a higher incidence in East Asians. We perform single-cell RNA sequencing for 63,394 cells …

Single-cell genomics enables dissection of tumor heterogeneity and molecular
underpinnings of drug response at an unprecedented resolution,,,,,,,,,–. However, broad …

Understanding the evolutionary pathways to metastasis and resistance to immune-
checkpoint inhibitors (ICI) in melanoma is critical for improving outcomes. Here, we present …

Brain metastases represent an important clinical problem for patients with small-cell lung
cancer (SCLC). However, the mechanisms underlying SCLC growth in the brain remain …

Biological membranes often play important functional roles in biomimetic drug delivery
systems. We discover that the circulation time and targeting capability of biological …