Fragile X syndrome (FXS), a heritable intellectual and autism spectrum disorder (ASD),
results from the loss of Fragile X mental retardation protein (FMRP). This …

Intellectual disability (ID) and autism are hallmarks of Fragile X Syndrome (FXS), a
hereditary neurodevelopmental disorder. The gene responsible for FXS is Fragile X Mental …

Accurate measurement of the amount of specific protein a cell produces is important for
investigating basic molecular processes. We have developed a technique that allows for …

Down syndrome (DS) is caused by the trisomy of human chromosome 21 (HSA21). A major
challenge in DS research is to identify the HSA21 genes that cause specific symptoms …

Mutations in some cell adhesion molecules (CAMs) cause abnormal synapse formation and
maturation, and serve as one of the potential mechanisms of autism spectrum disorders …

DSCAM and DSCAML 1 are immunoglobulin and cell adhesion‐type receptors serving
important neurodevelopmental functions including control of axon growth, branching, neurite …

Although many aspects of optic pathway development are beginning to be understood, the
mechanisms promoting the growth of retinal ganglion cell (RGC) axons toward visual targets …

Human chromosome 21 (Hsa21) contains more than 500 genes, making trisomy 21 one of
the most complex genetic perturbations compatible with life. The ultimate goal of Down …

Drosophila melanogaster Down syndrome cell adhesion molecule 1 (Dscam1) encodes
19,008 diverse ectodomain isoforms via the alternative splicing of exon 4, 6, and 9 clusters …

Elevated activity of retrotransposons is increasingly recognized to be implicated in a wide
range of neurodegenerative and neurodevelopmental diseases, including Down syndrome …