The mammalian target of rapamycin, mTOR is the master regulator of a cell's growth and
metabolic state in response to nutrients, growth factors and many extracellular cues. Its …

Anabolic resistance is defined by a blunted stimulation of muscle protein synthesis rates
(MPS) to common anabolic stimuli in skeletal muscle tissue such as dietary protein and …

The Akt/mechanistic target of rapamycin (mTOR) signaling pathway governs macromolecule
synthesis, cell growth, and metabolism in response to nutrients and growth factors …

We hypothesized that the maintenance of vascular homeostasis is critically dependent on
the expression and reciprocal regulation of caveolin-1 (Cav-1) and endothelial nitric oxide …

Muscle loss is an important feature that occurs in multiple pathologies including
osteoarthritis (OA), chronic obstructive pulmonary disease (COPD) and type II diabetes …

Improving the health of skeletal muscle is an important component of obesity treatment.
Apart from allowing for physical activity, skeletal muscle tissue is fundamental for the …

Regulated in development and DNA damage response 1 (REDD1) expression is
upregulated in response to metabolic imbalance and obesity. However, its role in obesity …

Regulated in development and DNA damage-response 1 (REDD1) is a stress-induced
protein that controls various cellular functions, including metabolism, oxidative stress …

Macrophages are essential inflammatory cells which regulate the features of immune
reactions within tumors. Many studies have reported their regulatory roles in immunity …

Insulin resistance and lower muscle quality (strength divided by mass) are hallmarks of type
2 diabetes (T2D). Here, we explore whether alterations in muscle stem cells (myoblasts) …