Results: It seems that persistent antigenic stimulation and oxidative stress from excessive
iron are the two main pathophysiologic factors of TM impacting the immune system …

Hemoglobinopathies though a monogenic disorder, show phenotypic variability. Hence,
understanding the genetics underlying the heritable sub-phenotypes of …

Patients with β-thalassemia suffer from a lack or absence of the beta-globin chain of normal
hemoglobin (Hb). Therefore, an increase in fetal Hb (HbF) levels could improve the clinical …

Hb F modulates sickle cell disease. Five major haplotypes of the β-globin gene cluster are
associated with sickle cell disease. In the Eastern Province of Saudi Arabia, the Arab-Indian …

HbF induction is an appropriate strategy to ameliorate the severity of β-thalassemia
symptoms. Hydroxyurea (HU) is the most common chemical agent introduced as an HbF …

Objective: The aim of this study was to determine frequency of secondary modifiers in non-
transfusion dependent thalassemia. Methods: This descriptive cross sectional study was …

Introduction: Hemolysis is a fundamental feature that contributes to hypercoagulability and
thrombotic complications in sickle cell disease (SCD). Factor V Leiden (FVL) and …

Background: One of the most important phenotypic modifying factors for thalassemia is the
presence of Xmn1 polymorphism. This retrospective study was performed to investigate the …

Background: Thalassemia syndromes are the most prevalent hereditary
hemoglobinopathies in the world. Iran is located on the thalassemia belt. In this study, the …

Objective: Beta thalassemia carriers (BTC) in Turkey is observed with a frequency of 2.1%,
and it is the most common cause of anemia after iron deficiency. There are few studies …