Pharmaceutical and medicinal significance of sulfur (SVI)-Containing motifs for drug discovery: A critical review

C Zhao, KP Rakesh, L Ravidar, WY Fang… - European journal of …, 2019 - Elsevier
Sulfur (S VI) based moieties, especially, the sulfonyl or sulfonamide based analogues have
showed a variety of pharmacological properties, and its derivatives propose a high degree …

Recent applications of vinyl sulfone motif in drug design and discovery

R Ahmadi, S Emami - European Journal of Medicinal Chemistry, 2022 - Elsevier
Vinyl sulfone with electrophilic character is not only a versatile building block for various
organic transformations but also is a key structural unit in a large number of biologically …

Recent development of sulfonyl or sulfonamide hybrids as potential anticancer agents: A key review

KP Rakesh, SM Wang, J Leng… - Anti-Cancer Agents …, 2018 - ingentaconnect.com
Cancer is the second leading cause of death worldwide. There is always a huge demand for
novel anticancer drugs and diverse new natural or synthetic compounds are developed …

Cross-Electrophile Coupling of Benzyl Halides and Disulfides Catalyzed by Iron

J Semenya, Y Yang, E Picazo - Journal of the American Chemical …, 2024 - ACS Publications
Cross-electrophile couplings are influential reactions that typically require a terminal
reductant or photoredox conditions. We discovered an iron-catalyzed reaction that couples …

Design, synthesis and QSAR study of certain isatin-pyridine hybrids as potential anti-proliferative agents

WM Eldehna, A Altoukhy, H Mahrous… - European Journal of …, 2015 - Elsevier
A hybrid pharmacophore approach was adopted to design and synthesize new series of
isatin–pyridine hybrids. All the newly prepared hybrids (5a–o, 8 and 11a–d) were in vitro …

Pyridines and Imidazopyridines with medicinal significance

T LS Kishbaugh - Current Topics in Medicinal Chemistry, 2016 - ingentaconnect.com
Pyridine and pyridine-fused ring systems are ubiquitous in medicinal research and
demonstrate such diverse pharmacological benefits as anticonvulsant therapies, treatment …

Pyridine-ureas as potential anticancer agents: synthesis and in vitro biological evaluation

M El-Naggar, H Almahli, HS Ibrahim, WM Eldehna… - Molecules, 2018 - mdpi.com
In our endeavor towards the development of effective anticancer agents, a novel series of
pyridine-ureas 8a–n were synthesized. All the newly prepared derivatives were evaluated in …

The vinyl sulfone motif as a structural unit for novel drug design and discovery

YC Xiao, FE Chen - Expert Opinion on Drug Discovery, 2024 - Taylor & Francis
Introduction Vinyl sulfones are a special sulfur-containing structural unit that have attracted
considerable attention, owing to their important role in serving as key structural motifs of …

Targeting CDK9 for treatment of colorectal cancer

MH Rahaman, F Lam, L Zhong, T Teo… - Molecular …, 2019 - Wiley Online Library
Colorectal cancer (CRC) remains one of the most lethal human malignancies, and pursuit of
new therapeutic targets for treatment has been a major research focus. Cyclin‐dependent …

Development and validation of an ICP-MS method for the determination of elemental impurities in TP-6076 active pharmaceutical ingredient (API) according to USP< …

O Chahrour, J Malone, M Collins, V Salmon… - … of pharmaceutical and …, 2017 - Elsevier
The new guidelines of the United States pharmacopeia (USP), European pharmacopeia
(EP) and international conference on harmonization (ICH) regulating elemental impurities …