Poly-adenosine diphosphate-ribose polymerases (PARPs) promote ADP-ribosylation, a
highly conserved, fundamental posttranslational modification (PTM). PARP catalytic …

Brain ischemia and reperfusion engage multiple independently-fatal terminal pathways
involving loss of membrane integrity in partitioning ions, progressive proteolysis, and …

Mice lacking the gene encoding poly (ADP-ribosyl) transferase (PARP or ADPRT) display no
phenotypic abnormalities, although aged mice are susceptible to epidermal hyperplasia and …

Poly (ADP-ribosyl) ation is an important mechanism for the maintenance of genomic integrity
in response to DNA damage. The enzyme responsible for poly (ADP-ribose) synthesis, poly …

Poly (ADP-ribose) polymerase is a zinc-finger DNA-binding enzyme which detects and
signals DNA strand breaks generated either directly during base excision repair, or indirectly …

Retroviral DNA integration is catalyzed by the viral protein integrase. Here, it is shown that
DNA-dependent protein kinase (DNA-PK), a host cell protein, also participates in the …

Diverse mobile DNA elements are believed to pirate host cell enzymes to complete DNA
transfer. Prominent examples are provided by retroviral cDNA integration and transposon …

RNA viruses are a genetically diverse group of pathogens that are responsible for some of
the most prevalent and lethal human diseases. Numerous viruses introduce DNA damage …

Since the discovery of HIV as the cause for AIDS 30 years ago, major progress has been
made, including the discovery of drugs that now control the disease. Here, we review the …

Poly (ADP-ribosyl) ation is a posttranslational modification of nuclear proteins which is
catalyzed by poly (ADP-ribose) polymerase and represents an immediate response of …