The liver is a central organ for homeostasis with unique regenerative capacities. Mature
hepatocytes possess a remarkable capacity to proliferate upon injury, challenging efforts to …

The liver is an organ with critical importance for drug treatment as the disposition and
response to a given drug is often determined by its hepatic metabolism. Patient-specific …

We report the fabrication of a scaffold (hereafter referred to as AngioChip) that supports the
assembly of parenchymal cells on a mechanically tunable matrix surrounding a perfusable …

Alveolar epithelial type II cells (AEC2s) are the facultative progenitors of lung alveoli and
serve as the surfactant-producing cells of air-breathing organisms. Although primary human …

Although bile duct disorders are well-recognized causes of liver disease, the molecular and
cellular events leading to biliary dysfunction are poorly understood. To enable modeling and …

We report the generation of human ESC-derived, expandable hepatic organoids (hEHOs)
using our newly established method with wholly defined (serum-free, feeder free) media …

Obtaining fully functional cell types is a major challenge for drug discovery and regenerative
medicine. Currently, a fundamental solution to this key problem is still lacking. Here, we …

How are closely related lineages, including liver, pancreas, and intestines, diversified from a
common endodermal origin? Here, we apply principles learned from developmental biology …

Liver disease is an important clinical problem, impacting over 30 million Americans and over
600 million people worldwide. It is the 12th leading cause of death in the United States and …

Liver cell types derived from induced pluripotent stem cells (iPSCs) share the potential to
investigate development, toxicity, as well as genetic and infectious disease in ways currently …