The subtelomeres, highly heterogeneous repeated sequences neighboring telomeres, are
transcribed into coding and noncoding RNAs in a variety of organisms. Telomereproximal …

No organism can avoid the process of aging, which is often accompanied by chronic
disease. The process of biological aging is driven by a series of interrelated mechanisms …

Telomeres are structures made of DNA, proteins and RNA found at the ends of eukaryotic
linear chromosomes. These dynamic nucleoprotein structures protect chromosomal tips from …

Telomere-linked RecQ helicase (tlh) genes have been reported in several fungi and a
choanoflagellate in the regions adjacent to the terminal telomere repeats. In this study, we …

In most eukaryotes, subtelomeres are dynamic genomic regions populated by multi-copy
sequences of different origins, which can promote segmental duplications and chromosomal …

Purpose Early identification of neurocognitive disorder (cognitive impairment) in older adults
is critical and necessary. Early identification allows for additional time for prevention efforts …

Telomeres are part of the system that guards genome integrity in eukaryotes, protecting
linear chromosomes from fusions and degradations. The protective functions of telomeres …

Background Accumulating evidence links disruptions in phospholipid homeostasis to
obesity, type 2 diabetes, and fatty liver diseases. Mice with a heterozygous ablation of the …

This chapter discusses past and present findings in S. cerevisiae concerning telomeres and
telomerase, most of which have revealed evolutionarily conserved biological mechanisms …

The effect of telomeres on aging and cancer is very important. Telomere is a necessary
structure for the continuous preliferation of human cells and is vital for most cancer cells …