[HTML][HTML] MicroRNA and cancer

MD Jansson, AH Lund - Molecular oncology, 2012 - Elsevier
With the advent of next generation sequencing techniques a previously unknown world of
non-coding RNA molecules have been discovered. Non-coding RNA transcripts likely …

The role of miRNAs in regulating gene expression networks

AM Gurtan, PA Sharp - Journal of molecular biology, 2013 - Elsevier
MicroRNAs (miRNAs) are key regulators of gene expression. They are conserved across
species, expressed across cell types, and active against a large proportion of the …

Prediction of microRNAs Associated with Human Diseases Based on Weighted k Most Similar Neighbors

P Xuan, K Han, M Guo, Y Guo, J Li, J Ding, Y Liu… - PloS one, 2013 - journals.plos.org
Background The identification of human disease-related microRNAs (disease miRNAs) is
important for further investigating their involvement in the pathogenesis of diseases. More …

[HTML][HTML] Long noncoding RNA ANRIL indicates a poor prognosis of gastric cancer and promotes tumor growth by epigenetically silencing of miR-99a/miR-449a

E Zhang, R Kong, D Yin, L You, M Sun, L Han, T Xu… - Oncotarget, 2014 - ncbi.nlm.nih.gov
Long noncoding RNAs are involved in diseases including cancer. Here, we reported that
ANRIL (CDKN2B-AS1), a 3.8-kb long noncoding RNA, recruiting and binding to PRC2, was …

[HTML][HTML] MicroRNAs and the cell cycle

MJ Bueno, M Malumbres - Biochimica et Biophysica Acta (BBA)-Molecular …, 2011 - Elsevier
The control of cell proliferation by microRNAs (miRNAs) is well established and the
alteration of these small, non-coding RNAs may contribute to tumor development by …

Epigenetics and microRNAs in cancer

A Ramassone, S Pagotto, A Veronese… - International journal of …, 2018 - mdpi.com
The ability to reprogram the transcriptional circuitry by remodeling the three-dimensional
structure of the genome is exploited by cancer cells to promote tumorigenesis. This …

Interplay between microRNAs and the epigenetic machinery: an intricate network

MV Iorio, C Piovan, CM Croce - Biochimica et Biophysica Acta (BBA)-Gene …, 2010 - Elsevier
microRNAs take their place into the epigenetic world revealing a complicated network of
reciprocal interconnections: not only they are able to control gene expression at a post …

Cancer hallmarks and microRNAs: the therapeutic connection

K Van Roosbroeck, GA Calin - Advances in cancer research, 2017 - Elsevier
Human cancers are characterized by a number of hallmarks, including sustained
proliferative signaling, evasion of growth suppressors, activated invasion and metastasis …

Control of vertebrate multiciliogenesis by miR-449 through direct repression of the Delta/Notch pathway

B Marcet, B Chevalier, G Luxardi, C Coraux… - Nature cell …, 2011 - nature.com
Multiciliated cells lining the surface of some vertebrate epithelia are essential for various
physiological processes, such as airway cleansing,,. However, the mechanisms governing …

MicroRNA-449 and microRNA-34b/c function redundantly in murine testes by targeting E2F transcription factor-retinoblastoma protein (E2F-pRb) pathway

J Bao, D Li, L Wang, J Wu, Y Hu, Z Wang… - Journal of Biological …, 2012 - ASBMB
MicroRNAs (miRNAs) mainly function as post-transcriptional regulators and are involved in
a wide range of physiological and pathophysiological processes such as cell proliferation …