Bacteria provide a rich source of natural products with potential therapeutic applications,
such as novel antibiotic classes or anticancer drugs. Bioactivity-guided screening of …

Covering: 2006 to 2016 The computational mining of genomes has become an important
part in the discovery of novel natural products as drug leads. Thousands of bacterial …

In complex biological systems, small molecules often mediate microbe-microbe and microbe-
host interactions. Using a systematic approach, we identified 3,118 small-molecule …

Starting with the earliest Streptomyces genome sequences, the promise of natural product
genome mining has been captivating: genomics and bioinformatics would transform …

Many eukaryotes have obligate associations with microorganisms that are transmitted
directly between generations. A model for heritable symbiosis is the association of aphids, a …

Covering: through 2014 Many organisms team up with microbes for defense against
predators, parasites, parasitoids, or pathogens. Here we review the described protective …

Covering 2000 to June 2015 This review discusses the biosynthesis of natural products that
are generated by trans-AT polyketide synthases, a family of catalytically versatile enzymes …

Insects share an intimate relationship with their gut microflora and this symbiotic association
has developed into an essential evolutionary outcome intended for their survival through …

Endozoicomonas bacteria are emerging as extremely diverse and flexible symbionts of
numerous marine hosts inhabiting oceans worldwide. Their hosts range from simple …

Lichens, which are defined by a core symbiosis between a mycobiont (fungal partner) and a
photobiont (photoautotrophic partner), are in fact complex assemblages of microorganisms …