The insulin receptor (IR) gene undergoes differential splicing that generates two IR isoforms,
IR-A and IR-B. The physiological roles of IR isoforms are incompletely understood and …

Estrogens play a critical role in many aspects of physiology, particularly female reproductive
function, but also in pathophysiology, and are associated with protection from numerous …

The G protein-coupled estrogen receptor (GPER) is a seven-transmembrane-domain
receptor that mediates non-genomic estrogen related signaling. After ligand activation …

In metabolic conditions such as obesity and diabetes, which are associated with
deregulated signaling of the insulin/insulin-like growth factor system (IIGFs), inflammation …

Autophagy dysfunctions are involved in the pathogenesis of Parkinson's disease (PD). In the
present study, we aimed to evaluate the involvement of G protein-coupled estrogen receptor …

Background The G protein estrogen receptor GPER/GPR30 mediates estrogen action in
breast cancer cells as well as in breast cancer-associated fibroblasts (CAFs), which are key …

Estrogen action is mediated by various genes, including estrogen-responsive genes
(ERGs). ERGs have been used as reporter-genes and markers for gene expression. Gene …

The synthetic peptide ERα17p (sequence: PLMIKRSKKNSLALSLT), which corresponds to
the 295–311 region of the human estrogen receptor α (ERα), induces apoptosis in breast …

The development and progression of the great majority of breast cancers (BCs) are mainly
dependent on the biological action elicited by estrogens through the classical estrogen …

Simple Summary Exogenous and endogenous estrogens and associated receptors
modulate signaling pathways with biochemical events implicated in non-small cell lung …