Nicotinamide adenine dinucleotide (NAD), the cell's hydrogen carrier for redox enzymes, is
well known for its role in redox reactions. More recently, it has emerged as a signaling …

Significance: Antioxidant and redox signaling (ARS) events are regulated by critical
molecules that modulate antioxidants, reactive oxygen species (ROS) or reactive nitrogen …

Abstract The sirtuins (SIRT1–7) are a family of nicotinamide adenine dinucleotide (NAD+)-
dependent deacylases with remarkable abilities to prevent diseases and even reverse …

The NAD+-dependent protein lysine deacylases of the Sirtuin family regulate various
physiological functions, from energy metabolism to stress responses. The human Sirtuin …

Mitochondria are a major target in hypoxic/ischemic injury. Mitochondrial impairment
increases with age leading to dysregulation of molecular pathways linked to mitochondria …

Sirtuins (SIRT), first discovered in yeast as NAD+ dependent epigenetic and metabolic
regulators, have comparable activities in human physiology and disease. Mounting …

Aging is the leading risk factor for several age-associated diseases such as
neurodegenerative diseases. Understanding the biology of aging mechanisms is essential …

Yeast Sir2 is a heterochromatin component that silences transcription at silent mating loci,
telomeres and the ribosomal DNA,, and that also suppresses recombination in the rDNA and …

The SIR genes are determinants of life span in yeast mother cells. Here we show that life
span regulation by the Sir proteins is independent of their role in nonhomologous end …

Sirtuins are a conserved family of proteins found in all domains of life. The first known sirtuin,
Sir2 (silent information regulator 2) of Saccharomyces cerevisia e, from which the family …