Virus recognition of glycan receptors
Highlights•Most mammalian virus families use cell-surface glycans as receptors.•Glycan
receptors are diverse in structure and distribution, giving rise to species and tissue …
receptors are diverse in structure and distribution, giving rise to species and tissue …
Glycosphingolipid–protein interaction in signal transduction
Glycosphingolipids (GSLs) are a class of ceramide-based glycolipids essential for embryo
development in mammals. The synthesis of specific GSLs depends on the expression of …
development in mammals. The synthesis of specific GSLs depends on the expression of …
Gangliosides are essential endosomal receptors for quasi-enveloped and naked hepatitis A virus
The Picornaviridae are a diverse family of positive-strand RNA viruses that includes
numerous human and veterinary pathogens. Among these, hepatitis A virus (HAV), a …
numerous human and veterinary pathogens. Among these, hepatitis A virus (HAV), a …
Organization of gangliosides into membrane nanodomains
Gangliosides are glycosphingolipids consisting of a ceramide base and a bulky sugar chain
that contains one or more sialic acids. This unique structure endows gangliosides with a …
that contains one or more sialic acids. This unique structure endows gangliosides with a …
Activation of PI3K, Akt, and ERK during early rotavirus infection leads to V-ATPase-dependent endosomal acidification required for uncoating
The cellular PI3K/Akt and/or MEK/ERK signaling pathways mediate the entry process or
endosomal acidification during infection of many viruses. However, their roles in the early …
endosomal acidification during infection of many viruses. However, their roles in the early …
Porcine deltacoronavirus utilizes sialic acid as an attachment receptor and trypsin can influence the binding activity
Y Yuan, S Zu, Y Zhang, F Zhao, X Jin, H Hu - Viruses, 2021 - mdpi.com
Porcine deltacoronavirus (PDCoV) is a novel coronavirus that causes diarrhea in nursing
piglets. Studies showed that PDCoV uses porcine aminopeptidase N (pAPN) as an entry …
piglets. Studies showed that PDCoV uses porcine aminopeptidase N (pAPN) as an entry …
Rotavirus-induced early activation of the RhoA/ROCK/MLC signaling pathway mediates the disruption of tight junctions in polarized MDCK cells
Intestinal epithelial tight junctions (TJ) are a major barrier restricting the entry of various
harmful factors including pathogens; however, they also represent an important entry portal …
harmful factors including pathogens; however, they also represent an important entry portal …
[HTML][HTML] Lamprey immunity protein enables early detection and recurrence monitoring for bladder cancer through recognizing Neu5Gc-modified uromodulin …
H Teng, Q Li, M Gou, G Liu, X Cao, J Lu, Y Han… - … et Biophysica Acta (BBA …, 2022 - Elsevier
The clinical management of bladder cancer (BCa) is hindered by the lack of reliable
biomarkers. We aimed to investigate the potential of lamprey immunity protein (LIP), a lectin …
biomarkers. We aimed to investigate the potential of lamprey immunity protein (LIP), a lectin …
Glycan chains of gangliosides: functional ligands for tissue lectins (siglecs/galectins)
RW Ledeen, J Kopitz, J Abad-Rodríguez… - Progress in Molecular …, 2018 - Elsevier
Molecular signals on the cell surface are responsible for adhesion and communication. Of
relevance in this respect, their chemical properties endow carbohydrates with the capacity to …
relevance in this respect, their chemical properties endow carbohydrates with the capacity to …
Dual recognition of sialic acid and αGal epitopes by the VP8* domains of the bovine rotavirus G6P [5] WC3 and of its mono-reassortant G4P [5] RotaTeq vaccine …
Group A rotaviruses, an important cause of severe diarrhea in children and young animals,
initiate infection via interactions of the VP8* domain of the VP4 spike protein with cell surface …
initiate infection via interactions of the VP8* domain of the VP4 spike protein with cell surface …