Extracellular nucleotides (eg, ATP, ADP, UTP, UDP) released by inflammatory cells interact
with specific purinergic P2 type receptors to modulate their recruitment and activation. The …

Adenosine triphosphate (ATP) has been well established as an important extracellular
ligand of autocrine signaling, intercellular communication, and neurotransmission with …

Nucleotides play a crucial role in extracellular signaling across species boundaries. All the
three kingdoms of life (Bacteria, Archea and Eukariota) are responsive to extracellular ATP …

Purinergic signaling is a cell communication pathway mediated by extracellular nucleotides
and nucleosides. Tri-and diphosphonucleotides are released in physiological and …

Post-translational modifications of connexins play an important role in the regulation of gap
junction and hemichannel permeability. The prerequisite for the formation of functional gap …

Pannexin 1 (Panx1) forms plasma membrane ion channels that are widely expressed
throughout the body. Panx1 activation results in the release of nucleotides such as …

Background & Aims The concept of enteric glia as regulators of intestinal homeostasis is
slowly gaining acceptance as a central concept in neurogastroenterology. Yet how glia …

Pannexins form channels at the plasma membrane surface that establish a pathway for
communication between the cytosol of individual cells and their extracellular environment …

Abstract Pannexin‐1 (Panx1) is a large pore membrane channel with unique conduction
properties ranging from non‐selective ion permeability to the extracellular release of …

Tumours are complex systems formed by cellular (malignant, immune, and endothelial cells,
fibroblasts) and acellular components (extracellular matrix (ECM) constituents and secreted …