Rhizobia induce nodule formation on legume roots and differentiate into bacteroids, which
catabolize plant-derived dicarboxylates to reduce atmospheric N2 into ammonia. Despite …

Cell metabolism is the biochemical machinery that provides energy and building blocks to
sustain life. Understanding its fine regulation is of pivotal relevance in several fields, from …

The development of high-throughput 'omic techniques has sparked a rising interest in
genome-scale metabolic models, with applications ranging from disease diagnostics to crop …

Metabolic reprogramming is a general feature of cancer cells. Regrettably, the
comprehensive quantification of metabolites in biological specimens does not promptly …

Cancer cells share several metabolic traits, including aerobic production of lactate from
glucose (Warburg effect), extensive glutamine utilization and impaired mitochondrial …

Metabolism is directly and indirectly fine-tuned by a complex web of interacting regulatory
mechanisms that fall into two major classes. On the one hand, the expression level of the …

The metabolic rearrangements occurring in cancer cells can be effectively investigated with
a Systems Biology approach supported by metabolic network modeling. We here present …

Motivation Intratumour heterogeneity poses many challenges to the treatment of cancer.
Unfortunately, the transcriptional and metabolic information retrieved by currently available …

The links between metabolic dysfunctions and various diseases or pathological conditions
are being increasingly revealed. This revival of interest in cellular metabolism has pushed …

Many high‐throughput post‐genomics (‐omics) technologies have been developed to
unravel cellular complexity and to investigate biological systems. Each‐omics technology …