Highlights•Recent crystal structures reveal insights into ligand promiscuity within the POT
family.•Selectivity pockets play important roles in peptide recognition and …

The SLC15 family of proton-coupled solute carriers PepT1 and PepT2 play a central role in
human physiology as the principal route for acquiring and retaining dietary nitrogen. A …

A high content of seed glucosinolates and their degradation products imposes anti‐
nutritional effects on livestock; therefore, persistent efforts are made to reduce the seed GSL …

Solute carrier (SLC) transporters play important roles in regulating the movement of small
molecules and ions across cellular membranes. In mammals, they play an important role in …

Despite vast diversity in metabolites and the matching substrate specificity of their
transporters, little is known about how evolution of transporter substrate specificities is linked …

A major challenge in drug development is the optimization of intestinal absorption and
cellular uptake. A successful strategy has been to develop prodrug molecules, which hijack …

Proton-dependent oligopeptide transporters (POTs) are promiscuous transporters of the
major facilitator superfamily that constitute the main route of entry for a wide range of dietary …

The uptake and elimination of beta-lactam antibiotics in the human body are facilitated by
the proton-coupled peptide transporters PepT1 (SLC15A1) and PepT2 (SLC15A2). The …

Based on recent in vitro data, a relatively large number of the plant nitrate transporter
1/peptide transporter family (NPF) proteins have been suggested to function as gibberellic …

Proton-coupled Oligopeptide Transporters (POTs) of the Major Facilitator Superfamily (MFS)
mediate the uptake of short di-and tripeptides in all phyla of life. POTs are thought to …