Is early-onset cancer an emerging global epidemic? Current evidence and future implications

T Ugai, N Sasamoto, HY Lee, M Ando… - Nature Reviews …, 2022 - nature.com
Over the past several decades, the incidence of early-onset cancers, often defined as
cancers diagnosed in adults< 50 years of age, in the breast, colorectum, endometrium …

Obesity, metabolic syndrome, and cancer: pathophysiological and therapeutic associations

N Mili, SA Paschou, DG Goulis, MA Dimopoulos… - Endocrine, 2021 - Springer
Overweight, obesity, and metabolic syndrome (MetS) have become epidemic conditions
affecting 39%, 13%, and 20% of the population respectively. The aim of this article is to …

The triple health threat of diabetes, obesity, and cancer—epidemiology, disparities, mechanisms, and interventions

JC Brown, TL Carson, HJ Thompson, T Agurs‐Collins - Obesity, 2021 - Wiley Online Library
Obesity and type 2 diabetes are both chronic, relapsing, progressive diseases that are
recognized as risk factors for the development of multiple types of cancer. In a recent …

Application of SHAP for explainable machine learning on age-based subgrouping mammography questionnaire data for positive mammography prediction and risk …

J Sun, CK Sun, YX Tang, TC Liu, CJ Lu - Healthcare, 2023 - mdpi.com
Mammography is considered the gold standard for breast cancer screening. Multiple risk
factors that affect breast cancer development have been identified; however, there is an …

Response to immune checkpoint blockade improved in pre-clinical model of breast cancer after bariatric surgery

LM Sipe, M Chaib, EB Korba, H Jo, MC Lovely… - Elife, 2022 - elifesciences.org
Bariatric surgery is a sustainable weight loss approach, including vertical sleeve
gastrectomy (VSG). Obesity exacerbates tumor growth, while diet-induced weight loss …

Crown-like structures in breast adipose tissue: early evidence and current issues in breast cancer

ML Maliniak, J Miller-Kleinhenz, DP Cronin-Fenton… - Cancers, 2021 - mdpi.com
Simple Summary Obesity increases the risk of postmenopausal, hormone receptor-positive
breast cancer and has been linked to a higher risk of recurrence and mortality. During …

Effect of high-intensity interval training combined with fasting in the treatment of overweight and obese adults: A systematic review and meta-analysis

Z Guo, J Cai, Z Wu, W Gong - International Journal of Environmental …, 2022 - mdpi.com
Objectives: A systematic review and meta-analysis is conducted to compare the effects of
high-intensity interval training (HIIT) combined with fasting (HIIT+ fasting) and other …

[HTML][HTML] Risk factors behind the increase of early-onset cancer in Italian adolescents and young adults: An investigation from the Italian AYA Working group

A Toss, C Piombino, P Quarello, A Trama… - European Journal of …, 2024 - Elsevier
The incidence of early-onset cancers in adolescents and young adults (AYA) has been
increasing worldwide since the 1990s. In Italy, a significant increased rate of 1.6% per year …

Occupational risk factors and breast cancer in Beijing, China: a hospital-based case–control study

A Li, Z Shen, Z Sun, S Yun, X Tian, Z Hu, G Yu, L Hu… - BMJ open, 2022 - bmjopen.bmj.com
Introduction Studies on the association between breast cancer and occupational hazards
are limited, especially in China. This is the first study to explore the relationship between …

Adiposity, Body Composition Measures, and Breast Cancer Risk in Korean Premenopausal Women

TXM Tran, Y Chang, HR Choi, R Kwon… - JAMA Network …, 2024 - jamanetwork.com
Objective To investigate the association between body composition parameters and breast
cancer (BC) risk in premenopausal women. Design, Setting, and Participants Prospective …