Integrative multi-omics landscape of fluoxetine action across 27 brain regions reveals global increase in energy metabolism and region-specific chromatin remodelling

NA Rayan, V Kumar, J Aow, N Rastegar, MGL Lim… - Molecular …, 2022 - nature.com
Depression and anxiety are major global health burdens. Although SSRIs targeting the
serotonergic system are prescribed over 200 million times annually, they have variable …

Ketamine alleviates PTSD-like effect and improves hippocampal synaptic plasticity via regulation of GSK-3β/GR signaling of rats

Z Wang, X Hu, Z Wang, J Chen, L Wang, C Li… - Journal of Psychiatric …, 2024 - Elsevier
Abstract Background Each year, 3–4% of the global population experiences post-traumatic
stress disorder (PTSD), a chronic mental disorder with significant social and economic …

Gene expression signatures of response to fluoxetine treatment: systematic review and meta-analyses

DG Cooper, JP Cowden, PA Stanley, JT Karbowski… - bioRxiv, 2024 - biorxiv.org
Background Selecting the best antidepressant for a patient with major depressive disorder
(MDD) remains a challenge, and some have turned to genomic (and other 'omic) data to …

[PDF][PDF] Gene expression signatures of response to fluoxetine treatment: systematic review and meta-analyses

S Gaertig, CJ Lukan, PM Vo, AD Worthington, CA Class - scholar.archive.org
Background: Selecting the best antidepressant for a patient with major depressive disorder
(MDD) remains a challenge, and some have turned to genomic (and other 'omic) data to …