Calcium (Ca2+) is a unique mineral that serves as both a nutrient and a signal in all
eukaryotes. To maintain Ca2+ homeostasis for both nutrition and signaling purposes, the …

Ion channels play a central role in the regulation of nearly every cellular process. Dating
back to the classic 1952 Hodgkin–Huxley model of the generation of the action potential, ion …

Precise signalling between pollen tubes and synergid cells in the ovule initiates fertilization
in flowering plants. Contact of the pollen tube with the ovule triggers calcium spiking in the …

The ability of the brain to store and process information relies on changing the strength of
connections between neurons. Synaptic facilitation is a form of short-term plasticity that …

Chemical synapses are heterogeneous junctions formed between neurons that are
specialized for the conversion of electrical impulses into the exocytotic release of …

GCaMP, one popular type of genetically-encoded Ca2+ indicator, has been associated with
various side-effects. Here we unveil the intrinsic problem prevailing over different versions …

All movements are generated by the activation of motoneurons, and hence their input-output
properties define the final step in processing of all motor commands. A major challenge to …

The Cav3. 2 subtype of T-type calcium channels has been targeted for developing
analgesics and anti-epileptics for its role in pain and epilepsy. Here we present the cryo-EM …

Abstract Background Cav1. 3 voltage-gated L-type calcium channels (LTCCs) are part of
postsynaptic neuronal signaling networks. They play a key role in brain function, including …

The identification of a gain-of-function mutation in CACNA1C as the cause of Timothy
syndrome, a rare disorder characterized by cardiac arrhythmias and syndactyly, highlighted …