The emerging tale of microglia in psychiatric disorders
As the professional phagocytes of the brain, microglia orchestrate the immunological
response and play an increasingly important role in maintaining homeostatic brain functions …
response and play an increasingly important role in maintaining homeostatic brain functions …
[HTML][HTML] Neuroimmune signaling in alcohol use disorder
Alcohol use disorder (AUD) is a widespread disease with limited treatment options.
Targeting the neuroimmune system is a new avenue for developing or repurposing effective …
Targeting the neuroimmune system is a new avenue for developing or repurposing effective …
Inflaming the brain with iron
Iron accumulation and neuroinflammation are pathological conditions found in several
neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease …
neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease …
Neuroinflammation in addiction: A review of neuroimaging studies and potential immunotherapies
Addiction is a worldwide public health problem and this article reviews scientific advances in
identifying the role of neuroinflammation in the genesis, maintenance, and treatment of …
identifying the role of neuroinflammation in the genesis, maintenance, and treatment of …
Neuroimmune mechanisms of opioid use disorder and recovery: Translatability to human studies, and future research directions
ER Butelman, RZ Goldstein, CA Nwaneshiudu… - Neuroscience, 2023 - Elsevier
Opioid use disorder (OUD) is a major current cause of morbidity and mortality. Long-term
exposure to short-acting opioids (MOP-r agonists such as heroin or fentanyl) results in …
exposure to short-acting opioids (MOP-r agonists such as heroin or fentanyl) results in …
Chronic alcohol-induced neuroinflammation involves CCR2/5-dependent peripheral macrophage infiltration and microglia alterations
PP Lowe, C Morel, A Ambade, A Iracheta-Vellve… - Journal of …, 2020 - Springer
Background Chronic alcohol consumption is associated with neuroinflammation, neuronal
damage, and behavioral alterations including addiction. Alcohol-induced neuroinflammation …
damage, and behavioral alterations including addiction. Alcohol-induced neuroinflammation …
Ketogenic diet reduces alcohol withdrawal symptoms in humans and alcohol intake in rodents
CE Wiers, LF Vendruscolo, W van Der Veen… - Science …, 2021 - science.org
Individuals with alcohol use disorder (AUD) show elevated brain metabolism of acetate at
the expense of glucose. We hypothesized that a shift in energy substrates during withdrawal …
the expense of glucose. We hypothesized that a shift in energy substrates during withdrawal …
Effects of age, BMI and sex on the glial cell marker TSPO — a multicentre [11C]PBR28 HRRT PET study
Purpose The purpose of this study was to investigate the effects of ageing, sex and body
mass index (BMI) on translocator protein (TSPO) availability in healthy subjects using …
mass index (BMI) on translocator protein (TSPO) availability in healthy subjects using …
The 18-kDa translocator protein PET tracers as a diagnostic marker for neuroinflammation: development and current standing
Translocator protein (TSPO, 18 kDa) is an evolutionary, well-preserved, and tryptophan-rich
169-amino-acid protein which localizes on the contact sites between the outer and inner …
169-amino-acid protein which localizes on the contact sites between the outer and inner …
Addictions NeuroImaging Assessment (ANIA): Towards an integrative framework for alcohol use disorder
Alcohol misuse and addiction are major international public health issues. Addiction can be
characterized as a disorder of aberrant neurocircuitry interacting with environmental, genetic …
characterized as a disorder of aberrant neurocircuitry interacting with environmental, genetic …