TRP (Transient receptor potential) channels are integral membrane proteins consisting of a
superfamily of cation channels that allow permeability of both monovalent and divalent …

Monocytes and macrophages play important roles in health and disease. They have a
central role in protecting the host, as they clear pathogens and modulate other immune cell …

Altered microenvironmental stiffness is a hallmark of inflammation. It is sensed by the
mechanically activated cation channel Piezo1 in macrophages to induce subsequent …

The role of GRP94, an endoplasmic reticulum (ER) stress protein with both pro-and anti-
inflammatory functions, has not been investigated in macrophages during ER stress …

Macrophage plasticity is essential for innate immunity, but in-depth signaling mechanism (s)
regulating their functional phenotypes are ill-defined. Here we report that interferon (IFN) γ …

Calcium (Ca2+) and magnesium (Mg2+) ions have been shown to play an important role in
regulating various neuronal functions. In the present review we focus on the emerging role …

Calcium is a major intracellular signaling messenger in innate immune cells. Similar to other
immune cell subsets, the majority of calcium entry into innate immune cells is induced by cell …

When host cells are exposed to foreign particles, dead cells, or cell hazards, a sophisticated
process called phagocytosis begins. During this process, macrophages, dendritic cells, and …

Macrophages/microglia with M2-activation phenotype are thought to play important anti-
inflammatory and tissue reparative functions in the brain, yet the molecular bases of their …

The pore-forming S. aureus α-toxin (Hla) contributes to virulence and disease pathogenesis.
While high concentrations of toxin induce cell death, neutrophils exhibit relative resistance to …