An accurate understanding of the clonal origins of tumors is critical for designing effective
strategies to treat or prevent cancer and for guiding the field of cancer risk assessment. The …

Being the second leading cause of death globally, cancer has been a long-standing and
rapidly evolving focus of biomedical research and practice in the world. A tremendous effort …

BACKGROUND: Cancer incidence and mortality increase with age through much of
adulthood, but earlier work has found that these rates decline among the very elderly. To …

Various molecular and cellular pathways are active in eukaryotes to control the quality and
integrity of mitochondria. These pathways are involved in keeping a 'healthy'population of …

Tobacco smoking was considered by previous IARC Working Groups in 1986, 1987 and
2002 (IARC, 1986, 1987, 2004a). Since that time, new data have become available, these …

Aim: This study quantified low-frequency KRAS mutations in normal lung and lung
adenocarcinomas, to understand their potential significance in the development of acquired …

Probiotics and related preparations, including synbiotics and postbiotics, are living and non-
living microbial-based multi-components, which are now among the most popular bioactive …

Abstract Background Standardized Nucleic Acid Quantification for SEQuencing (SNAQ-
SEQ) is a novel method that utilizes synthetic DNA internal standards spiked into each …

A non-eukaryotic, metakaryotic cell with large, open mouthed, bell shaped nuclei represents
an important stem cell lineage in fetal/juvenile organogenesis in humans and rodents. Each …

High throughput means to detect and quantify low‐frequency mutations (< 10− 2) in the DNA‐
coding sequences of human tissues and pathological lesions are required to discover the …