From a clinical, morphological and molecular perspective, prostate cancer is a
heterogeneous disease. Primary prostate cancers are often multifocal, having …

Single-cell sequencing (SCS) has impacted many areas of cancer research and improved
our understanding of intratumor heterogeneity, the tumor microenvironment, metastasis, and …

Although p53 inactivation promotes genomic instability and presents a route to malignancy
for more than half of all human cancers,, the patterns through which heterogenous TP53 …

Improvements in whole genome amplification (WGA) would enable new types of basic and
applied biomedical research, including studies of intratissue genetic diversity that require …

Localized prostate cancer shows great clinical, genetic and environmental heterogeneity;
however, prostate cancer treatment is currently guided solely by clinical staging, serum PSA …

Abstract Background and Objective: Prostate cancer is one of the most prevalent forms of
cancer in men worldwide. Traditional screening strategies such as serum PSA levels, which …

Copy number alterations (CNAs) play an important role in molding the genomes of breast
cancers and have been shown to be clinically useful for prognostic and therapeutic …

Men taking antioxidant vitamin E supplements have increased prostate cancer (PC) risk.
However, whether pro-oxidants protect from PC remained unclear. In this work, we show that …

Context Studies characterising genomic changes in prostate cancer (PCa) during natural
progression have greatly increased our understanding of the disease. A better …

The single cell is considered the basic unit of biology, and the pursuit of understanding how
heterogeneous populations of cells can functionally coexist in tissues, organisms, microbial …