The spindle assembly checkpoint (SAC) is a surveillance mechanism that promotes
accurate chromosome segregation in mitosis. The checkpoint senses the attachment state of …

The microtubule minus-end-directed motility of cytoplasmic dynein 1 (dynein), arguably the
most complex and versatile cytoskeletal motor, is harnessed for diverse functions, such as …

Chromosome biorientation on the mitotic spindle is prerequisite to errorless genome
inheritance. CENP‐E (kinesin‐7) and dynein–dynactin (DD), microtubule motors with …

The efficacy of current antimitotic cancer drugs is limited by toxicity in highly proliferative
healthy tissues. A cancer-specific dependency on the microtubule motor protein KIF18A …

In metazoans, a≈ 1 megadalton (MDa) multiprotein complex comprising the dynein–
dynactin adaptor Spindly and the ROD–Zwilch–ZW10 (RZZ) complex is the building block of …

Kinetochore protein phosphorylation promotes the correction of erroneous microtubule
attachments to ensure faithful chromosome segregation during cell division. Determining …

Local phosphatase regulation is needed at kinetochores to silence the mitotic checkpoint
(aka spindle assembly checkpoint [SAC]). A key event in this regard is the …

Measuring the dynamics with which the regulatory complexes assemble and disassemble is
a crucial barrier to our understanding of how the cell cycle is controlled that until now has …

Kinetochores are multi-protein machines that form dynamic attachments to microtubules and
control chromosome segregation. High fidelity is ensured because kinetochores can monitor …

Abstract Cyclin‐dependent kinases (CDKs), the master regulators of cell division, are
activated by different cyclins at different cell cycle stages. In addition to being activators of …