Acute pain signaling has a key protective role and is highly evolutionarily conserved.
Chronic pain, however, is maladaptive, occurring as a consequence of injury and disease …

The effective and safe treatment of pain is an unmet health-care need. Current medications
used for pain management are often only partially effective, carry dose-limiting adverse …

Evidence from human genetic pain disorders shows that voltage-gated sodium channel α-
subtypes Nav1. 7, Nav1. 8 and Nav1. 9 are important in the peripheral signalling of pain …

After nerve injury maladaptive changes can occur in injured sensory neurons and along the
entire nociceptive pathway within the CNS, which may lead to spontaneous pain or pain …

The transmission and processing of pain signals relies critically on the activities of ion
channels that are expressed in afferent pain fibers. This includes voltage-gated channels, as …

The highly disagreeable sensation of pain results from an extraordinarily complex and
interactive series of mechanisms integrated at all levels of the neuroaxis, from the periphery …

Injuries to the peripheral nerves result in partial or total loss of motor, sensory and autonomic
functions conveyed by the lesioned nerves to the denervated segments of the body, due to …

Nociception is essential for survival whereas pathological pain is maladaptive and often
unresponsive to pharmacotherapy. Voltage-gated sodium channels, Nav1. 1–Nav1. 9, are …

DORSAL root ganglion sensory neurons associated with C-fibres, many of which are
activated by tissue-damage, express an unusual voltage-gated sodium channel that is …

The activity of voltage-gated sodium channels has long been linked to disorders of neuronal
excitability such as epilepsy and chronic pain. Recent genetic studies have now expanded …