Alzheimer's disease (AD) is the most common form of dementia, and is a multi-faceted
disease that is characterized by oxidative stress, metal-ion dysregulation, and the formation …

Metal ions play a key role in aggregation of amyloid β protein by interfering with their proper
folding, altering protein homeostasis and cell viability, and ultimately leading to …

Unlike amyloid aggregates, amorphous protein aggregates with no defined structures have
been challenging to target and detect in a complex cellular milieu. In this study, we rationally …

Metal chelation can provide structural stability and form reactive centers in metalloproteins.
Approximately one third of known protein structures are metalloproteins, and metal binding …

Alzheimer's disease (AD) is the most common form of dementia, where one of the
pathological hallmarks of AD is extracellular protein deposits, the primary component of …

Coordination complexes have emerged as prominent modulators of amyloid aggregation via
their interaction with the N-terminal histidine residues of amyloid-β (Aβ). Herein, we report …

Aggregation of amyloid-β (Aβ) peptides is implicated in the development of Alzheimer's
disease (AD), the most common type of dementia. Thus, numerous efforts to identify …

Alzheimer's disease (AD) is currently an incurable neurodegenerative disorder that affects
millions of people around the world. The aggregation of amyloid-β peptides (Aβ), one of the …

Neurodegenerative disorders (NDDs) are a class of debilitating diseases that progressively
impair the protein structure and result in neurological dysfunction in the nervous system …

Many incurable or unmanageable human protein conformational diseases are associated
with the misfolding or aggregation of the aberrantly processed or mutant proteins. In this …