Glucose oxidase, an enzyme “Ferrari”: Its structure, function, production and properties in the light of various industrial and biotechnological applications

JA Bauer, M Zámocká, J Majtán, V Bauerová-Hlinková - Biomolecules, 2022 - mdpi.com
Glucose oxidase (GOx) is an important oxidoreductase enzyme with many important roles in
biological processes. It is considered an “ideal enzyme” and is often called an oxidase …

Same substrate, many reactions: oxygen activation in flavoenzymes

E Romero, JR Gómez Castellanos, G Gadda… - Chemical …, 2018 - ACS Publications
Over time, organisms have evolved strategies to cope with the abundance of dioxygen on
Earth. Oxygen-utilizing enzymes tightly control the reactions involving O2 mostly by …

CAVER 3.0: a tool for the analysis of transport pathways in dynamic protein structures

E Chovancova, A Pavelka, P Benes, O Strnad… - 2012 - journals.plos.org
Tunnels and channels facilitate the transport of small molecules, ions and water solvent in a
large variety of proteins. Characteristics of individual transport pathways, including their …

[HTML][HTML] Gates of enzymes

A Gora, J Brezovsky, J Damborsky - Chemical reviews, 2013 - ACS Publications
Enzymes are very efficient catalysts that are essential for the functioning of living organisms.
The low efficiency of biocatalysts produced de novo relative to those that have evolved …

To be or not to be an oxidase: challenging the oxygen reactivity of flavoenzymes

A Mattevi - Trends in biochemical sciences, 2006 - cell.com
Flavin-dependent enzymes catalyse a wide range of reactions and, thereby, facilitate a
variety of cellular processes. Among the properties that equip flavoenzymes with this …

Directed evolution unlocks oxygen reactivity for a nicotine-degrading flavoenzyme

M Dulchavsky, R Mitra, K Wu, J Li, K Boer, X Liu… - Nature Chemical …, 2023 - nature.com
The flavoenzyme nicotine oxidoreductase (NicA2) is a promising injectable treatment to aid
in the cessation of smoking, a behavior responsible for one in ten deaths worldwide. NicA2 …

Catabolism and biotechnological applications of cholesterol degrading bacteria

JL García, I Uhía, B Galán - Microbial biotechnology, 2012 - Wiley Online Library
Cholesterol is a steroid commonly found in nature with a great relevance in biology,
medicine and chemistry, playing an essential role as a structural component of animal cell …

Flavoprotein oxidases: classification and applications

WP Dijkman, G de Gonzalo, A Mattevi… - Applied Microbiology and …, 2013 - Springer
This review provides an overview of oxidases that utilise a flavin cofactor for catalysis. This
class of oxidative flavoenzymes has shown to harbour a large number of biotechnologically …

What's in a covalent bond? On the role and formation of covalently bound flavin cofactors

DPHM Heuts, NS Scrutton, WS McIntire… - The FEBS …, 2009 - Wiley Online Library
Many enzymes use one or more cofactors, such as biotin, heme, or flavin. These cofactors
may be bound to the enzyme in a noncovalent or covalent manner. Although most …

An overview on alcohol oxidases and their potential applications

P Goswami, SSR Chinnadayyala… - Applied Microbiology …, 2013 - Springer
Abstract Alcohol oxidases (Alcohol: O 2 Oxidoreductase; EC 1.1. 3. x) are flavoenzymes that
catalyze the oxidation of alcohols to the corresponding carbonyl compounds with a …