[HTML][HTML] Anti-viral triterpenes: a review
P Darshani, S Sen Sarma, AK Srivastava… - Phytochemistry …, 2022 - Springer
Triterpenes are naturally occurring derivatives biosynthesized following the isoprene rule of
Ruzicka. The triterpenes have been reported to possess a wide range of therapeutic …
Ruzicka. The triterpenes have been reported to possess a wide range of therapeutic …
Potential of coronavirus 3C-like protease inhibitors for the development of new anti-SARS-CoV-2 drugs: Insights from structures of protease and inhibitors
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), similar to SARS-CoV and
Middle East respiratory syndrome coronavirus (MERS-CoV), which belong to the same …
Middle East respiratory syndrome coronavirus (MERS-CoV), which belong to the same …
Structure and inhibition of the SARS-CoV-2 main protease reveal strategy for developing dual inhibitors against Mpro and cathepsin L
The main protease (Mpro) of SARS-CoV-2 is a key antiviral drug target. While most Mpro
inhibitors have a γ-lactam glutamine surrogate at the P1 position, we recently found that …
inhibitors have a γ-lactam glutamine surrogate at the P1 position, we recently found that …
What coronavirus 3C‐like protease tells us: from structure, substrate selectivity, to inhibitor design
M Xiong, H Su, W Zhao, H Xie… - Medicinal Research …, 2021 - Wiley Online Library
The emergence of a variety of coronaviruses (CoVs) in the last decades has posed huge
threats to human health. Especially, the ongoing pandemic of coronavirus disease 2019 …
threats to human health. Especially, the ongoing pandemic of coronavirus disease 2019 …
Can phytotherapy with polyphenols serve as a powerful approach for the prevention and therapy tool of novel coronavirus disease 2019 (COVID-19)?
E Levy, E Delvin, V Marcil… - American Journal of …, 2020 - journals.physiology.org
Much more serious than the previous severe acute respiratory syndrome (SARS)
coronavirus (CoV) outbreaks, the novel SARS-CoV-2 infection has spread speedily …
coronavirus (CoV) outbreaks, the novel SARS-CoV-2 infection has spread speedily …
Porcine epidemic diarrhea virus: Molecular mechanisms of attenuation and vaccines
Z Li, Z Ma, Y Li, S Gao, S Xiao - Microbial pathogenesis, 2020 - Elsevier
Porcine epidemic diarrhea virus (PEDV) causes an emerging and re-emerging coronavirus
disease characterized by vomiting, acute diarrhea, dehydration, and up to 100% mortality in …
disease characterized by vomiting, acute diarrhea, dehydration, and up to 100% mortality in …
[HTML][HTML] Structural basis of SARS-CoV-2 main protease inhibition by a broad-spectrum anti-coronaviral drug
Abstract The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) or 2019 novel coronavirus (2019-nCoV) …
respiratory syndrome coronavirus 2 (SARS-CoV-2) or 2019 novel coronavirus (2019-nCoV) …
Coronaviruses Nsp5 antagonizes porcine gasdermin D-mediated pyroptosis by cleaving pore-forming p30 fragment
F Shi, Q Lv, T Wang, J Xu, W Xu, Y Shi, X Fu, T Yang… - MBio, 2022 - Am Soc Microbiol
Coronaviruses (CoVs) are a family of RNA viruses that typically cause respiratory, enteric,
and hepatic diseases in animals and humans. Here, we use porcine epidemic diarrhea virus …
and hepatic diseases in animals and humans. Here, we use porcine epidemic diarrhea virus …
[HTML][HTML] Tannic acid suppresses SARS-CoV-2 as a dual inhibitor of the viral main protease and the cellular TMPRSS2 protease
The cell surface protein TMPRSS2 (transmembrane protease serine 2) is an androgen-
responsive serine protease important for prostate cancer progression and therefore an …
responsive serine protease important for prostate cancer progression and therefore an …
In silico study of azithromycin, chloroquine and hydroxychloroquine and their potential mechanisms of action against SARS-CoV-2 infection
HLB Braz, JA de Moraes Silveira, AD Marinho… - International journal of …, 2020 - Elsevier
ABSTRACT Coronavirus disease 2019 (COVID-19) is a highly transmissible viral infection
caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Clinical trials …
caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Clinical trials …