Oxidative stress and diseases associated with high-altitude exposure

E Pena, S El Alam, P Siques, J Brito - Antioxidants, 2022 - mdpi.com
Several diseases associated with high-altitude exposure affect unacclimated individuals.
These diseases include acute mountain sickness (AMS), high-altitude cerebral edema …

Impact of high altitude on cardiovascular health: current perspectives

RT Mallet, J Burtscher, JP Richalet… - Vascular health and …, 2021 - Taylor & Francis
Globally, about 400 million people reside at terrestrial altitudes above 1500 m, and more
than 100 million lowlanders visit mountainous areas above 2500 m annually. The …

Hyperbaric oxygen therapy counters oxidative stress/inflammation-driven symptoms in long COVID-19 patients: preliminary outcomes

S Mrakic-Sposta, A Vezzoli, G Garetto, M Paganini… - Metabolites, 2023 - mdpi.com
Long COVID-19 patients show systemic inflammation and persistent symptoms such as
fatigue and malaise, profoundly affecting their quality of life. Since improving oxygenation …

Oxidative Stress Response Kinetics after 60 Minutes at Different Levels (10% or 15%) of Normobaric Hypoxia Exposure

C Leveque, S Mrakic Sposta, S Theunissen… - International journal of …, 2023 - mdpi.com
In this study, the metabolic responses of hypoxic breathing for 1 h to inspired fractions of
10% and 15% oxygen were investigated. To this end, 14 healthy nonsmoking subjects (6 …

Effects of prolonged exposure to hypobaric hypoxia on oxidative stress: overwintering in Antarctic Concordia Station

S Mrakic-Sposta, M Montorsi, S Porcelli… - Oxidative Medicine …, 2022 - Wiley Online Library
Concordia Station is the permanent, research station on the Antarctic Plateau at 3230 m.
During the eleventh winter‐over campaign (DC11‐2015; February 2015 to November 2015) …

Protective effects of the Terminalia bellirica tannin-induced Nrf2/HO-1 signaling pathway in rats with high-altitude pulmonary hypertension

S Aimaier, Y Tao, F Lei, Z Yupeng, S Wenhui… - … Medicine and Therapies, 2023 - Springer
Background Oxidative stress and endothelial cell dysfunction induced by high-altitude
hypoxia have important roles in the pathological process of high-altitude pulmonary …

[HTML][HTML] Consumption of Sylimarin, Pyrroloquinoline Quinone Sodium Salt and Myricetin: Effects on Alcohol Levels and Markers of Oxidative Stress—A Pilot Study

G Bosco, A Vezzoli, A Brizzolari, M Paganini… - Nutrients, 2024 - mdpi.com
Background: Alcohol abuse is one of the most common causes of mortality worldwide. This
study aimed to investigate the efficacy of a treatment in reducing circulating ethanol and …

Chelation Therapy Associated with Antioxidant Supplementation Can Decrease Oxidative Stress and Inflammation in Multiple Sclerosis: Preliminary Results

A Vezzoli, S Mrakic-Sposta, C Dellanoce, M Montorsi… - Antioxidants, 2023 - mdpi.com
An imbalance of oxy-inflammation status has been involved in axonal damage and
demyelination in multiple sclerosis (MS). The aim of this study was to investigate the efficacy …

Impact of high-altitude hypoxia on bone defect repair: A review of molecular mechanisms and therapeutic implications

P Chen, Y Liu, W Liu, Y Wang, Z Liu, M Rong - Frontiers in Medicine, 2022 - frontiersin.org
Reaching areas at altitudes over 2,500–3,000 m above sea level has become increasingly
common due to commerce, military deployment, tourism, and entertainment. The high …

The “ON-OFF” Switching Response of Reactive Oxygen Species in Acute Normobaric Hypoxia: Preliminary Outcome

S Mrakic-Sposta, M Gussoni, M Marzorati… - International journal of …, 2023 - mdpi.com
Exposure to acute normobaric hypoxia (NH) elicits reactive oxygen species (ROS)
accumulation, whose production kinetics and oxidative damage were here investigated …