Traditional drug discovery mainly focuses on direct regulation of protein activity. The
development and application of protein activity modulators, particularly inhibitors, has been …

Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are
neurodegenerative disorders that exist on a disease spectrum due to pathological, clinical …

Nuclear clearance and cytoplasmic mislocalization of the essential RNA binding protein,
TDP-43, is a pathologic hallmark of amyotrophic lateral sclerosis, frontotemporal dementia …

Ubiquitin signaling is a sequence of events driving the fate of a protein based on the type of
ubiquitin modifications attached. In the case of neurodegenerative diseases, ubiquitin …

Alterations in autophagy and the ubiquitin proteasome system (UPS) are commonly
implicated in protein aggregation and toxicity which manifest in a number of neurological …

The proper functioning of the cell clearance machinery is critical for neuronal health within
the central nervous system (CNS). In normal physiological conditions, the cell clearance …

Background Cytoplasmic inclusions of transactive response DNA binding protein of 43 kDa
(TDP-43) in neurons and astrocytes are a feature of some neurodegenerative diseases …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder that causes the
progressive loss of motoneurons and, unfortunately, there is no effective treatment for this …

Amyotrophic lateral sclerosis (ALS) is a progressive and fatal neurodegenerative disease
that leads to the massive loss of motor neurons in cerebrum, brain stem and spinal cord. It …

p62 is a versatile protein involved in the delicate balance between cell death and survival,
which is fundamental for cell fate decision in the context of both cancer and …