Understanding how chromatin is folded in the nucleus is fundamental to understanding its
function. Although 3D genome organization has been historically difficult to study owing to a …

The raison d'être of meiosis is shuffling of genetic information via Mendelian segregation
and, within individual chromosomes, by DNA crossing-over. These outcomes are enabled …

The field of 3D genome organization produces large amounts of sequencing data from Hi-C
and a rapidly-expanding set of other chromosome conformation protocols (3C+). Massive …

Chromosome conformation capture (3C) technologies reveal the incredible complexity of
genome organization. Maps of increasing size, depth, and resolution are now used to probe …

Our understanding of the structure and function of mitotic chromosomes has come a long
way since these iconic objects were first recognized more than 140 years ago, though many …

The three-dimensional organization of the genome supports regulated gene expression,
recombination, DNA repair, and chromosome segregation during mitosis. Chromosome …

Homology search is a central step of DNA double-strand break (DSB) repair by homologous
recombination (HR). How it operates in cells remains elusive. We developed a Hi-C-based …

In bacteria, chromosome segregation occurs progressively from the origin to terminus within
minutes of replication of each locus. Between replication and segregation, sister loci are …

DNA replication ensures the precise transmission of genetic information from parent to
daughter cells. In eukaryotes, this process involves the replication of every base pair within a …

The statistics of triple contacts between the regions of an interphase chromosome in the
presence of an active loop extrusion mechanism is theoretically studied. When modeling …