Cell therapies aim to repair the mechanisms underlying disease initiation and progression,
achieved through trophic effect or by cell replacement. Multiple cell types can be utilized in …

Islet transplantation has proved one of the most remarkable transmissions from an
experimental curiosity into a routine clinical application for the treatment of type I diabetes …

Cases of type 2 diabetes mellitus have significantly increased in recent years. Researchers
worldwide are combining their knowledge of biology, medicine, tissue engineering, and …

Background Pancreatic islets are important in nutrient homeostasis and improved cellular
models of clonal origin may very useful especially in view of relatively scarce primary …

Cholinergic neurons can functionally support pancreatic islets in controlling blood sugar
levels. However, in islet transplantation, the level of cholinergic reinnervation is significantly …

Pancreatic islet transplantation has emerged as a promising treatment for type‐1 diabetes
(T1D); however, its clinical application is still limited by the life‐long use of …

Diabetes now is the most common chronic disease in the world inducing heavy burden for
the people's health. Based on this, diabetes research such as islet function has become a …

Background The functional quality of insulin-secreting islet beta cells is a major factor
determining the outcome of clinical transplantations for diabetes. It is therefore of importance …

Pancreatic islets have been the focus of recent studies exploring the pathologic mechanisms
of diabetes mellitus as well as more effective and radical treatments for this disease. Islet …

Diabetes mellitus is a chronic disease which affects over 425 million people worldwide
(2017), a number which is expected to rise to 629 million people by 2045. Diabetes mellitus …