The roles and regulation of the KLF5 transcription factor in cancers
Y Luo, C Chen - Cancer science, 2021 - Wiley Online Library
Krüppel‐like factor 5 (KLF5) is a member of the KLF family. Recent studies have suggested
that KLF5 regulates the expression of a large number of new target genes and participates …
that KLF5 regulates the expression of a large number of new target genes and participates …
Identification and validation of an individualized prognostic signature of bladder cancer based on seven immune related genes
H Qiu, X Hu, C He, B Yu, Y Li, J Li - Frontiers in genetics, 2020 - frontiersin.org
Background There has been no report of prognostic signature based on immune-related
genes (IRGs). This study aimed to develop an IRG-based prognostic signature that could …
genes (IRGs). This study aimed to develop an IRG-based prognostic signature that could …
[HTML][HTML] Development of prognostic signature based on immune-related genes in muscle-invasive bladder cancer: bioinformatics analysis of TCGA database
K Jin, S Qiu, D Jin, X Zhou, X Zheng, J Li, X Liao… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
Background: Muscle-invasive bladder cancer (MIBC) with high tumor stages accounts for
most bladder cancer patient mortality. Platinum-based chemotherapy provides insufficient …
most bladder cancer patient mortality. Platinum-based chemotherapy provides insufficient …
[HTML][HTML] CCL7 and TGF-β secreted by MSCs play opposite roles in regulating CRC metastasis in a KLF5/CXCL5-dependent manner
Z Xu, H Gao, Y Zhang, W Feng, Y Miao, Z Xu, W Li… - Molecular Therapy, 2022 - cell.com
CXCL5 is overexpressed in colorectal cancer (CRC) and promotes distant metastasis and
angiogenesis of tumors; however, the underlying mechanism that mediates CXCL5 …
angiogenesis of tumors; however, the underlying mechanism that mediates CXCL5 …
Derivation and validation of a prognostic model for cancer dependency genes based on CRISPR-Cas9 in gastric adenocarcinoma
W Zhou, J Li, X Lu, F Liu, T An, X Xiao, ZC Kuo… - Frontiers in …, 2021 - frontiersin.org
As a CRISPR-Cas9-based tool to help scientists to investigate gene functions, Cancer
Dependency Map genes (CDMs) include an enormous series of loss-of-function screens …
Dependency Map genes (CDMs) include an enormous series of loss-of-function screens …
Elevated heterogeneous nuclear ribonucleoprotein C expression correlates with poor prognosis in patients with surgically resected lung adenocarcinoma
W Guo, Q Huai, G Zhang, L Guo, P Song, X Xue… - Frontiers in …, 2021 - frontiersin.org
Background Lung adenocarcinoma (LUAD), as the most common histological subtype of
lung cancer, is a high-grade malignancy and a leading cause of cancer-related death …
lung cancer, is a high-grade malignancy and a leading cause of cancer-related death …
Krüppel-like factor 5 regulates wound repair and the innate immune response in human airway epithelial cells
A complex network of transcription factors regulates genes involved in establishing and
maintaining key biological properties of the human airway epithelium. However, detailed …
maintaining key biological properties of the human airway epithelium. However, detailed …
siAKR1C3@ PPA complex nucleic acid nanoparticles inhibit castration-resistant prostate cancer in vitro
X Cui, Z Yao, T Zhao, J Guo, J Ding, S Zhang… - Frontiers in …, 2022 - frontiersin.org
Introduction AKR1C3, as a crucial androgenic enzyme, implicates the androgen
biosynthesis and promoting prostate cancer cell growth in vitro. This study provides a new …
biosynthesis and promoting prostate cancer cell growth in vitro. This study provides a new …
Identification of a novel immune microenvironment signature predicting survival and therapeutic options for bladder cancer
Y Yan, Z Huang, J Cai, P Tang, F Zhang… - Aging (Albany …, 2020 - pmc.ncbi.nlm.nih.gov
Few studies have investigated the potential of tumor immune microenvironment genes as
indicators of urinary bladder cancer. Here, we sought to establish an immune-related gene …
indicators of urinary bladder cancer. Here, we sought to establish an immune-related gene …
[HTML][HTML] Promoter-Specific Variants in NeuroD1 and H3K4me3 Coincident Regions and Clinical Outcomes of Small Cell Lung Cancer
SS Yoo, S Lee, JE Choi, MJ Hong… - Journal of Korean …, 2023 - synapse.koreamed.org
Background Neurogenic differentiation 1 (NeuroD1) is a representative small cell lung
cancer (SCLC) transcription regulator involved in the carcinogenesis and behavior of SCLC …
cancer (SCLC) transcription regulator involved in the carcinogenesis and behavior of SCLC …