Chemokines play well established roles as attractants of naïve and effector T cells. New
studies indicate that chemokines also have roles in regulating T cell differentiation. Blocking …

An effective inflammatory immune response first requires the recruitment of cells to the site of
inflammation and then their appropriate activation and regulation. Chemokines are critical in …

Background Alzheimer's disease (AD) is a progressive neurodegenerative disorder
characterized by pathological deposition of misfolded self-protein amyloid beta (Aβ) which in …

Skin lesions in atopic dermatitis (AD) are characterized by hypertrophy of the dermis and
epidermis, infiltration by T cells and eosinophils, and expression of the cytokines IL-4, IL-5 …

We analyzed for the first time the expression of chemokines in subpopulations of the murine
immune system at the single-cell level. We demonstrate in vitro and in a model of murine …

Current knowledge states that periodontal diseases are chronic inflammatory reactions
raised in response to periodontopathogens. Many cell types and mediators, including Th1 …

Asthma is an inflammatory disease of the airways that is induced by Th2 cytokines and
inhibited by Th1 cytokines. Despite a steady increase in the incidence, morbidity, and …

Th1 and Th2 T helper cell subsets affect patterns of injury and outcomes in
glomerulonephritis. The recognition that human immune responses can be directed by two …

Two novel human β-chemokines, Ckβ-8 or myeloid progenitor inhibitory factor 1 (MPIF-1),
and Ckβ-6 or MPIF-2, were discovered as part of a large scale cDNA sequencing effort. The …

T effector subsets, such as Th1 or Th2 cells, are key players in inflammatory reactions. It is
not known whether chemokines are able to recruit these subsets differentially, as has been …