Extracellular matrix (ECM) is a dynamic 3‐dimensional network of macromolecules that
provides structural support for the cells and tissues. Accumulated knowledge clearly …

Glycosaminoglycans are natural heteropolysaccharides that are present in every
mammalian tissue. They are composed of repeating disaccharide units that consist of either …

Glycosaminoglycans (GAGs) as one major part of the glycocalyx are involved in many
essential biological cell processes, as well as in many courses of diseases. Because of the …

Background Hyaluronan is a critical component of extracellular matrix with several different
roles. Besides the contribution to the tissue hydration, mechanical properties and correct …

Hyaluronan (HA) is a naturally occurring non-sulfated glycosaminoglycan (GAG) localized to
the cell surface and the tissue extracellular matrix (ECM). It is composed of disaccharides …

Damage to the endothelial glycocalyx, which helps maintain vascular homeostasis,
heightens the sensitivity of the vasculature to atherogenic stimuli. Patients with renal failure …

Breast cancer-induced inflammation in the tumor reactive stroma supports invasion and
malignant progression and is contributed to by a variety of host cells including macrophages …

Hyaluronic acid (HA) is key to the stability of the internal environment of tissues. HA content
in tissues gradually decreases with age, causing age-related health problems. Exogenous …

Objective: Endothelial cells exposed to laminar shear stress express a thick glycocalyx on
their surface that plays an important role in reducing vascular permeability and endothelial …

Transition from homeostatic to reactive matrix remodeling is a fundamental adaptive tissue
response to injury, inflammatory disease, fibrosis, and cancer. Alterations in architecture …