O‐GlcNAcylation: cellular physiology and therapeutic target for human diseases

L Ye, W Ding, D Xiao, Y Jia, Z Zhao, X Ao, J Wang - MedComm, 2023 - Wiley Online Library
Abstract O‐linked‐β‐N‐acetylglucosamine (O‐GlcNAcylation) is a distinctive
posttranslational protein modification involving the coordinated action of O‐GlcNAc …

Inhibition of O-glcnacylation reduces cell viability and autophagy and increases sensitivity to chemotherapeutic temozolomide in glioblastoma

AV Leonel, F Alisson-Silva, RCM Santos… - Cancers, 2023 - mdpi.com
Simple Summary Glioblastoma (GB) is the most common and aggressive type of malignant
brain tumor; however, despite advances in treatment modalities, it remains largely incurable …

The NF-κB Pathway: Key Players in neurocognitive functions and related disorders

D Yang, J Su, Y Chen, G Chen - European Journal of Pharmacology, 2024 - Elsevier
Perioperative neurocognitive disorder (PND) is a common complication of surgical
anesthesia, yet its precise etiology remains unclear. Neuroinflammation is a key feature of …

GFPT2: A novel biomarker in mesothelioma for diagnosis and prognosis and its molecular mechanism in malignant progression

J Wei, S Zhou, G Chen, T Chen, Y Wang, J Zou… - British Journal of …, 2024 - nature.com
Background Mesothelioma (MESO) is an insidious malignancy with a complex diagnosis
and a poor prognosis. Our study unveils Glutamine-Fructose-6-Phosphate Transaminase 2 …

Fucosyltransferase 8 regulates adult neurogenesis and cognition of mice by modulating the Itga6-PI3K/Akt signaling pathway

H Guo, Q Sun, X Huang, X Wang, F Zhang… - Science China Life …, 2024 - Springer
Abstract Fucosyltransferase 8 (Fut8) and core fucosylation play critical roles in regulating
various biological processes, including immune response, signal transduction, proteasomal …

Maternal Obesity and Kawasaki Disease-like Vasculitis: A New Perspective on Cardiovascular Injury and Inflammatory Response in Offspring Male Mice

Y Zheng, W Wang, Y Huo, Y Gui - Nutrients, 2023 - mdpi.com
Maternal obesity affects the risk of cardiovascular disease and inflammatory response in
offspring. However, the impact of maternal obesity on offspring with Kawasaki disease (KD) …

The oncogenic role and regulatory mechanism of ACAA2 in human ovarian cancer

Y Leng, T Tian, B Tang, Y Ma, Z Li, Q Shi… - Molecular …, 2024 - Wiley Online Library
Abstract Acetyl‐CoAacyltransferase2 (ACAA2) is a key enzyme in the fatty acid oxidation
pathway that catalyzes the final step of mitochondrial β oxidation, which plays an important …

DHM/SERS reveals cellular morphology and molecular changes during iPSCs-derived activation of astrocytes

X Bu, L Yang, X Han, S Liu, X Lu, J Wan… - Biomedical Optics …, 2024 - opg.optica.org
The activation of astrocytes derived from induced pluripotent stem cells (iPSCs) is of great
significance in neuroscience research, and it is crucial to obtain both cellular morphology …

[HTML][HTML] Sodium aescinate alleviates neuropathic pain through suppressing OGT-mediated O-GlcNAc modification of TLR3 to inactivate MAPK signaling pathway

R Chen, J Hu, Y Zhang, Y Liu, L Cao, F He… - Brain Research …, 2024 - Elsevier
Neuropathic pain results from damage to nerves or the brain, and is characterized by
symptoms such as allodynia, spontaneous pain, and hyperalgesia. The causes of this type …

O-GlcNAcylation: a pro-survival response to acute stress in the cardiovascular and central nervous systems

Q Xue, S Ji, H Xu, S Yu - European Journal of Medical Research, 2024 - Springer
O-GlcNAcylation is a unique monosaccharide modification that is ubiquitously present in
numerous nucleoplasmic and mitochondrial proteins. The hexosamine biosynthesis …