Sigma-1 receptor (S1R) is a multi-functional, ligand-operated protein situated in
endoplasmic reticulum (ER) membranes and changes in its function and/or expression have …

Increasing evidence in recent years indicates that protein misfolding and aggregation,
leading to ER stress, are central factors of pathogenicity in neurodegenerative diseases …

The complexity of affected brain regions and cell types is a challenge for Huntington's
disease (HD) treatment. Here we use single nucleus RNA sequencing to investigate …

Background The recent global pandemic has placed a high priority on identifying drugs to
prevent or lessen clinical infection of severe acute respiratory syndrome coronavirus 2 …

Huntington disease (HD) is a neurodegenerative disorder caused by polyglutamine-
encoding CAG repeat expansion in the huntingtin (HTT) gene. HTT is involved in the axonal …

The sigma-1 receptor is a 223 amino acid-long protein with a recently identified structure.
The sigma-2 receptor is a genetically unrelated protein with a similarly shaped binding …

Accumulation of misfolded proteins is a common phenomenon of several
neurodegenerative diseases. The misfolding of proteins due to abnormal polyglutamine …

Pridopidine is a selective Sigma-1 receptor (S1R) agonist in clinical development for
Huntington disease (HD) and amyotrophic lateral sclerosis. S1R is a chaperone protein …

The sigma-1 receptor (Sig-1R) is a chaperone receptor that primarily resides at the
mitochondria-associated endoplasmic reticulum (ER) membrane (MAM) and acts as a …

There is evidence that cognitive decline in Alzheimer's disease (AD) results from
deficiencies in synaptic communication (eg, loss of mushroom-shaped 'memory spines') and …