Severe traumatic brain injury (TBI) is currently managed in the intensive care unit with a
combined medical–surgical approach. Treatment aims to prevent additional brain damage …

Neurocritical care depends, in part, on careful patient monitoring but as yet there are little
data on what processes are the most important to monitor, how these should be monitored …

The incidence of traumatic brain injury (TBI) in the United States was 3.5 million cases in
2009, according to the Centers for Disease Control and Prevention. It is a contributing factor …

This review summarizes the (patho)-physiological effects of ventilation with high FiO 2 (0.8–
1.0), with a special focus on the most recent clinical evidence on its use for the management …

Objective: To determine whether paramedic rapid sequence intubation in patients with
severe traumatic brain injury (TBI) improves neurologic outcomes at 6 months compared …

Neuroprotective strategies that limit secondary tissue loss and/or improve functional
outcomes have been identified in multiple animal models of ischemic, hemorrhagic …

Molecular oxygen (O2) is a vital element in human survival and plays a major role in a
diverse range of biological and physiological processes. Although normobaric hyperoxia …

An association between hypoxemia and poor outcomes from traumatic brain injury (TBI) is
well documented. However, it is unclear whether hyperoxygenation is beneficial. This …

Purpose The effect of high arterial oxygen levels and supplemental oxygen administration
on outcomes in traumatic brain injury (TBI) is debated, and data from large cohorts of TBI …

Importance Combined oxygen 15–labeled positron emission tomography (15 O PET) and
brain tissue oximetry have demonstrated increased oxygen diffusion gradients in hypoxic …