Leishmania are protozoan parasites that predominantly reside in myeloid cells within their
mammalian hosts. Monocytes and macrophages play a central role in the pathogenesis of …

For a long time Leishmaniasis had been considered as a neglected tropical disease.
Recently, it has become a priority in public health all over the world for different aspects such …

Activation of the NLRP3 inflammasome by Leishmania parasites is critical for the outcome of
leishmaniasis, a disease that affects millions of people worldwide. We investigate the …

Aberrant macrophage activation during intracellular infection generates immunopathologies
that can cause severe human morbidity. A better understanding of immune subversion …

Leishmania RNA virus (LRV) is an important virulence factor associated with the
development of mucocutaneous Leishmaniasis, a severe form of the disease. LRV-mediated …

Leishmania parasites preferentially invade macrophages, the professional phagocytic cells,
at the site of infection. Macrophages play conflicting roles in Leishmania infection either by …

The pervasiveness of viral infectious agents, capable of parasitizing living organisms all
along the evolutionary spectrum, has obligated hosts to evolve defense mechanisms that …

The oxidative burst generated by the host immune system can restrict intracellular parasite
entry and growth. While this burst leads to the induction of antioxidative enzymes, the …

Highlights•Leishmania infection triggers activation of NLRP3 inflammasome in
macrophages.•Inflammasome activation in macrophages restricts intracellular parasite …

Inflammasomes are cytosolic complexes that assemble in response to cellular stress or
upon sensing microbial molecules, culminating in cytokine processing and an inflammatory …