The insulin-like growth factors (IGF-I and IGF-II) and their receptors are widely expressed in
nervous tissue from early embryonic life. They also cross the blood brain barriers by active …

Brain-derived neurotrophic factor (BDNF), a critical member of the neurotrophic family, plays
an important role in multiple stress-related mental disorders. Although alterations in BDNF in …

Early-life stress is a determinant of vulnerability to a variety of disorders that include
dysfunction of the brain and gut. Here we exploit a model of early-life stress, maternal …

Stress has long been associated with the development of neuropsychiatric and neurological
disorders. The effects of stress vary depending upon the age during which the stress is …

Rodent models are an indispensable tool for studying etiology and progress of depression.
Since interrelated systems of neurotrophic factors and cytokines comprise major regulatory …

Early life stress (ELS) is implicated in the etiology of multiple psychiatric disorders. Important
biological effects of ELS are manifested in stress-susceptible regions of the hippocampus …

Involvement of life stress in Late-Onset Alzheimer's Disease (LOAD) has been evinced in
longitudinal cohort epidemiological studies, and endocrinologic evidence suggests …

Depression is an illness of unknown origin and involves the dysregulation of many
physiological processes disturbed in this disease. It has been postulated that the …

Background Recent evidence suggests that brain-derived neurotrophic factor (BDNF) levels
and their early changes may predict antidepressant response in adults with major …

The brain-derived neurotrophic factor (BDNF) is a key regulator of neural development and
plasticity. Long-term changes in the BDNF pathway are associated with childhood adversity …