Tumor microenvironment enriches the stemness features: the architectural event of therapy resistance and metastasis

P Nallasamy, RK Nimmakayala, S Parte, AC Are… - Molecular cancer, 2022 - Springer
Cancer divergence has many facets other than being considered a genetic term. It is a
tremendous challenge to understand the metastasis and therapy response in cancer …

Therapeutic strategies targeting cancer stem cells and their microenvironment

HR Sun, S Wang, SC Yan, Y Zhang, PJ Nelson… - Frontiers in …, 2019 - frontiersin.org
Cancer stem cells (CSCs) have been demonstrated in a variety of tumors and are thought to
act as a clonogenic core for the genesis of new tumor growth. This small subpopulation of …

A graph-embedded deep feedforward network for disease outcome classification and feature selection using gene expression data

Y Kong, T Yu - Bioinformatics, 2018 - academic.oup.com
Motivation Gene expression data represents a unique challenge in predictive model
building, because of the small number of samples (n) compared with the huge amount of …

[HTML][HTML] Role of Notch signaling pathway in pancreatic cancer

J Gao, B Long, Z Wang - American journal of cancer research, 2017 - ncbi.nlm.nih.gov
Pancreatic cancer (PC) is one of the highly aggressive malignancies in the United States. It
has been shown that multiple signaling pathways are involved in the pathogenesis of PC …

[HTML][HTML] The role of TRAIL signaling in cancer: searching for new therapeutic strategies

C Luo, S He, F Shi, J Zhou, L Shang - Biology, 2024 - mdpi.com
Simple Summary In the realm of modern medicine, the battle against cancer is a relentless
pursuit that demands continuous innovation. Among the numerous elements in the complex …

TRAIL receptor-induced features of epithelial-to-mesenchymal transition increase tumour phenotypic heterogeneity: potential cell survival mechanisms

L Peyre, M Meyer, P Hofman, J Roux - British Journal of Cancer, 2021 - nature.com
The continuing efforts to exploit the death receptor agonists, such as the tumour necrosis
factor (TNF)-related apoptosis-inducing ligand (TRAIL), for cancer therapy, have largely …

Elaeagnus angustifolia Plant Extract Inhibits Epithelial-Mesenchymal Transition and Induces Apoptosis via HER2 Inactivation and JNK Pathway in HER2-Positive …

A Jabeen, A Sharma, I Gupta, H Kheraldine, S Vranic… - Molecules, 2020 - mdpi.com
Elaeagnus angustifolia (EA) is a medicinal plant used for treating several human diseases in
the Middle East. Meanwhile, the outcome of EA extract on HER2-positive breast cancer …

JNK in tumor microenvironment: present findings and challenges in clinical translation

SY Tam, HKW Law - Cancers, 2021 - mdpi.com
Simple Summary Stress-activated c-Jun N-terminal kinases (JNKs) are members of mitogen-
activated protein kinases (MAPKs). Apart from having both tumor promoting and tumor …

[HTML][HTML] Irreversible JNK1-JUN inhibition by JNK-IN-8 sensitizes pancreatic cancer to 5-FU/FOLFOX chemotherapy

MB Lipner, XL Peng, C Jin, Y Xu, Y Gao, MP East… - JCI insight, 2020 - ncbi.nlm.nih.gov
Over 55,000 people in the United States are diagnosed with pancreatic ductal
adenocarcinoma (PDAC) yearly, and fewer than 20% of these patients survive a year …

Oncogenic signaling pathways in pancreatic ductal adenocarcinoma

R Agrawal, KN Natarajan - Advances in Cancer Research, 2023 - Elsevier
Pancreatic ductal adenocarcinoma (PDAC) is the most common (∼ 90% cases) pancreatic
neoplasm and one of the most lethal cancer among all malignances. PDAC harbor aberrant …