Precisely controlled cell deformations are key to cell migration, division and tissue
morphogenesis, and have been implicated in cell differentiation during development, as well …

When animal cells enter mitosis, they round up to become spherical. This shape change is
accompanied by changes in mechanical properties. Multiple studies using different …

The cortex is a thin, crosslinked actin network lying immediately beneath the plasma
membrane of animal cells. Myosin motors exert contractile forces in the meshwork. Because …

Many aspects of cytoskeletal assembly and dynamics can be recapitulated in vitro; yet, how
the cytoskeleton integrates signals in vivo across cellular membranes is far less understood …

Crosstalk between the actin cytoskeleton and microtubules promotes symmetry break to
polarize cells for division, shape changes, and migration. These cellular events are crucial …

Animal cells undergo dramatic changes in shape, mechanics and polarity as they progress
through the different stages of cell division. These changes begin at mitotic entry, with cell …

Collective cell movements contribute to development and metastasis. The small GTPase
Rac is a key regulator of actin dynamics and cell migration but the mechanisms that restrict …

Microgravity induces changes in the cytoskeleton. This might have an impact on cells and
organs of humans in space. Unfortunately, studies of cytoskeletal changes in microgravity …

Cell division requires the precise coordination of chromosome segregation and cytokinesis.
This coordination is achieved by the recruitment of an actomyosin regulator, Ect2, to …

The plasma membrane serves as a barrier, separating the cell from its external environment.
Simultaneously it acts as a site for information transduction, entry of nutrients, receptor …