Methods for the Manipulation of Herpesvirus Genome and the Application to Marek's Disease Virus Research
Herpesviruses are a group of double-strand DNA viruses that infect a wide range of hosts,
including humans and animals. In the past decades, numerous methods have been …
including humans and animals. In the past decades, numerous methods have been …
A novel effective and safe vaccine for prevention of Marek's disease caused by infection with a very virulent plus (vv+) Marek's disease virus
Marek's disease virus (MDV) is a highly contagious alphaherpesvirus that causes rapid
onset lymphoma in chickens. Marek's disease (MD) is effectively controlled using …
onset lymphoma in chickens. Marek's disease (MD) is effectively controlled using …
Marek's disease virus US3 protein kinase phosphorylates chicken HDAC 1 and 2 and regulates viral replication and pathogenesis
Marek's disease virus (MDV) is a potent oncogenic alphaherpesvirus that elicits a rapid
onset of malignant T-cell lymphomas in chickens. Three MDV types, including GaHV-2 (MDV …
onset of malignant T-cell lymphomas in chickens. Three MDV types, including GaHV-2 (MDV …
Telomeric repeats in the commercial SB-1 vaccine facilitate viral integration and contribute to vaccine efficacy
Marek's disease virus (MDV) integrates its genome into the telomeres of host chromosomes
and causes fatal lymphomas in chickens. This integration is facilitated by telomeric repeat …
and causes fatal lymphomas in chickens. This integration is facilitated by telomeric repeat …
Marek's disease virus Meq oncoprotein interacts with chicken HDAC 1 and 2 and mediates their degradation via proteasome dependent pathway
Marek's disease virus (MDV) encodes a basic-leucine zipper (BZIP) protein, Meq, which is
considered the major MDV oncoprotein. It has been reported that the oncogenicity of Meq is …
considered the major MDV oncoprotein. It has been reported that the oncogenicity of Meq is …
Marek's disease virus cluster 3 miRNAs restrict virus' early cytolytic replication and pathogenesis
Herpesvirus-encoded microRNAs (miRNAs) have been discovered in infected cells;
however, lack of a suitable animal model has hampered functional analyses of viral miRNAs …
however, lack of a suitable animal model has hampered functional analyses of viral miRNAs …
[HTML][HTML] 家禽疱疹病毒CRISPR/Cas9 基因编辑最新研究进展
罗俊， 刘金玲， 郑鹿平， 罗琴， 滕蔓 - 畜牧兽医学报, 2022 - xml-data.org
基于CRISPR/Cas9 系统的基因编辑是最新一代的基因组编辑技术, 在向导RNA (gRNA)
的介导下几乎可以靶向编辑任何一种基因, 实现基因组的定点突变, 敲除或插入 …
的介导下几乎可以靶向编辑任何一种基因, 实现基因组的定点突变, 敲除或插入 …
Phenotypic Characterization of Recombinant Marek's Disease Virus in Live Birds Validates Polymorphisms Associated with Virulence
T Kim, CJ Hearn, J Mays, D Velez-Irizarry, SM Reddy… - Viruses, 2023 - mdpi.com
Marek's disease (MD) is a highly infectious lymphoproliferative disease in chickens with a
significant economic impact. Mardivirus gallidalpha 2, also known as Marek's disease virus …
significant economic impact. Mardivirus gallidalpha 2, also known as Marek's disease virus …
Highly virulent Marek's disease virus strains affect T lymphocyte function and viability of splenocytes in commercial meat-type chickens
IM Gimeno, AL Cortes, SM Reddy… - Avian …, 2019 - Taylor & Francis
In previous studies, we have demonstrated that very virulent plus Marek's disease viruses
(vv+ MDV) are highly immunosuppressive in commercial meat-type chickens. The specific …
(vv+ MDV) are highly immunosuppressive in commercial meat-type chickens. The specific …
Manipulation of promyelocytic leukemia protein nuclear bodies by Marek's disease virus encoded US3 protein kinase
Promyelocytic leukemia protein nuclear bodies (PML-NBs) are dynamic nuclear structures,
shown to be important for herpesvirus replication; however, their role in regulating Marek's …
shown to be important for herpesvirus replication; however, their role in regulating Marek's …