Osteoporosis is an important age-related bone disease characterized by increased bone
turnover with insufficient bone formation relative to bone resorption. According to the current …

Osteoporosis is defined as low bone mineral density associated with skeletal fractures
secondary to minimal or no trauma, most often involving the spine, the hip, and the forearm …

Parathyroid hormone (PTH) and the paracrine factor, PTH-related protein (PTHrP), have
preserved in evolution sufficient identities in their amino-terminal domains to share …

Although parathyroid hormone-related protein (PTHrP) was discovered as a cancer-derived
hormone, it has been revealed as an important paracrine/autocrine regulator in many …

The extracellular calcium-sensing receptor (CaSR) is the first identified G protein–coupled
receptor to be activated by an ion, extracellular calcium (Ca2+). Since the identification of …

Osteoporosis is a systemic disease that affects the skeleton, causing reduction of bone
density and mass, resulting in destruction of bone microstructure and increased risk of bone …

The actions of extracellular Ca 2+ in regulating parathyroid gland and kidney functions are
mediated by the extracellular calcium receptor (CaR), a G protein-coupled receptor. The …

The calcium-sensing receptor (CaSR), a key player in the maintenance of calcium
homeostasis, can influence bone modeling and remodeling by directly acting on bone cells …

Osteoporosis is an asymptomatic progressive disease. With the improvement of people's
living standard and the aging of population, osteoporosis and its fracture have become one …

Bone is continuously remodelled at many sites asynchronously throughout the skeleton, with
bone formation and resorption balanced at these sites to retain bone structure. Negative …